pathway title
Regulation of DNA replication
G alpha (i) signalling events
G alpha (q) signalling events
Signaling by EGFR
Assembly of the primary cilium
Signaling by ERBB2
M/G1 Transition
Activation of NMDA receptors and postsynaptic events
Ubiquinol biosynthesis
RHO GTPases Activate Rhotekin and Rhophilins
tRNA modification in the nucleus and cytosol
Response of EIF2AK4 (GCN2) to amino acid deficiency
Aspartate and asparagine metabolism
DNA Damage Reversal
Formation of Fibrin Clot (Clotting Cascade)
Metabolism of water-soluble vitamins and cofactors
Platelet homeostasis
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Signaling by Insulin receptor
Transport of glycerol from adipocytes to the liver by Aquaporins
ATF6 (ATF6-alpha) activates chaperone genes
Abacavir transport and metabolism
Meiotic synapsis
Interleukin-2 family signaling
Inositol phosphate metabolism
Mitotic Metaphase and Anaphase
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
MTOR signalling
RAF-independent MAPK1/3 activation
Signaling by FGFR2
Striated Muscle Contraction
Metallothioneins bind metals
Interleukin-17 signaling
Regulation of TP53 Activity through Methylation
Other interleukin signaling
Regulation of TLR by endogenous ligand
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Interleukin-15 signaling
Glutamate binding, activation of AMPA receptors and synaptic plasticity
Tryptophan catabolism
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Bile acid and bile salt metabolism
Cell junction organization
Mitotic G1 phase and G1/S transition
Nephrin family interactions
Semaphorin interactions
Growth hormone receptor signaling
Deadenylation-dependent mRNA decay
DAG and IP3 signaling
Metabolism of non-coding RNA
Erythrocytes take up carbon dioxide and release oxygen
Metabolism of steroid hormones
Hedgehog 'off' state
TNF signaling
Base-Excision Repair, AP Site Formation
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate
tRNA processing in the nucleus
DNA Damage/Telomere Stress Induced Senescence
RAB GEFs exchange GTP for GDP on RABs
Glycogen metabolism
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
Choline catabolism
Signaling by MET
Plasma lipoprotein assembly, remodeling, and clearance
Regulation of RUNX2 expression and activity
SUMOylation of DNA methylation proteins
SUMOylation of ubiquitinylation proteins
Activation of kainate receptors upon glutamate binding
Carnitine synthesis
Proline catabolism
Apoptotic execution phase
DNA Damage Bypass
Eukaryotic Translation Termination
Platelet Aggregation (Plug Formation)
Vasopressin regulates renal water homeostasis via Aquaporins
MHC class II antigen presentation
Host Interactions of HIV factors
Signaling by NOTCH1
MyD88 dependent cascade initiated on endosome
RHO GTPases activate CIT
Mismatch Repair
TRAIL  signaling
Metabolism of amine-derived hormones
Endosomal Sorting Complex Required For Transport (ESCRT)
Metabolism of folate and pterines
Lipid particle organization
Interconversion of nucleotide di- and triphosphates
Clathrin-mediated endocytosis
rRNA modification in the mitochondrion
Aryl hydrocarbon receptor signalling
Fatty acyl-CoA biosynthesis
Regulation of RUNX1 Expression and Activity
Listeria monocytogenes entry into host cells
Synthesis of Lipoxins (LX)
Biosynthesis of EPA-derived SPMs
SUMOylation of SUMOylation proteins
NGF-stimulated transcription
Events associated with phagocytolytic activity of PMN cells
Glutamate and glutamine metabolism
Circadian Clock
Integration of energy metabolism
Netrin-1 signaling
Neurotransmitter release cycle
Synthesis of DNA
Mitochondrial iron-sulfur cluster biogenesis
Mitochondrial protein import
Signaling by ERBB4
PRC2 methylates histones and DNA
RHO GTPases activate KTN1
Resolution of Abasic Sites (AP sites)
RHO GTPases Activate Formins
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
XBP1(S) activates chaperone genes
HDR through MMEJ (alt-NHEJ)
Pyrophosphate hydrolysis
G-protein beta:gamma signalling
COPII-mediated vesicle transport
Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism
SALM protein interactions at the synapse
NADPH regeneration
WNT ligand biogenesis and trafficking
G alpha (12/13) signalling events
Gap junction trafficking and regulation
Neurotransmitter clearance
Signal amplification
Signaling by Rho GTPases
Transport of inorganic cations/anions and amino acids/oligopeptides
Unfolded Protein Response (UPR)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Meiotic recombination
Extracellular matrix organization
Syndecan interactions
RHO GTPases regulate CFTR trafficking
Signaling by FGFR3
RHO GTPases activate PAKs
Caspase activation via Death Receptors in the presence of ligand
Sialic acid metabolism
SIRT1 negatively regulates rRNA expression
TET1,2,3 and TDG demethylate DNA
Amyloid fiber formation
ROS and RNS production in phagocytes
Fructose metabolism
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
Collagen chain trimerization
Ion channel transport
Galactose catabolism
Triglyceride metabolism
TYSND1 cleaves peroxisomal proteins
Blood group systems biosynthesis
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Creatine metabolism
Cell Cycle Checkpoints
Complement cascade
Dissolution of Fibrin Clot
Mitotic G2-G2/M phases
Neurotransmitter uptake and metabolism In glial cells
Signaling by ROBO receptors
Collagen degradation
Insulin processing
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
Visual phototransduction
Transcriptional regulation of pluripotent stem cells
Detoxification of Reactive Oxygen Species
Oncogene Induced Senescence
EPH-Ephrin signaling
RHO GTPases Activate ROCKs
DNA Double Strand Break Response
Wax and plasmalogen biosynthesis
Intestinal infectious diseases
Class C/3 (Metabotropic glutamate/pheromone receptors)
Signaling by PTK6
Peroxisomal protein import
p75 NTR receptor-mediated signalling
Transcriptional Regulation by VENTX
WNT5:FZD7-mediated leishmania damping
Advanced glycosylation endproduct receptor signaling
Eukaryotic Translation Elongation
Integrin cell surface interactions
NCAM signaling for neurite out-growth
Opioid Signalling
Iron uptake and transport
Interleukin-7 signaling
Cellular response to hypoxia
Metabolism of Angiotensinogen to Angiotensins
Signaling by Activin
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
Fanconi Anemia Pathway
Protein repair
Butyrophilin (BTN) family interactions
Glucose metabolism
Transcriptional regulation by RUNX3
Neurexins and neuroligins
Interleukin-9 signaling
STAT5 Activation
Class I peroxisomal membrane protein import
Anti-inflammatory response favouring Leishmania parasite infection
Latent infection - Other responses of Mtb to phagocytosis
NR1H2 and NR1H3-mediated signaling
Asparagine N-linked glycosylation
Eukaryotic Translation Initiation
Regulation of Apoptosis
Regulation of mRNA stability by proteins that bind AU-rich elements
Glycosaminoglycan metabolism
PI Metabolism
Neurotransmitter receptors and postsynaptic signal transmission
MAPK6/MAPK4 signaling
Uptake and function of anthrax toxins
TNFR2 non-canonical NF-kB pathway
Hedgehog ligand biogenesis
Vitamin D (calciferol) metabolism
Threonine catabolism
TP53 Regulates Transcription of DNA Repair Genes
Cardiac conduction
B-WICH complex positively regulates rRNA expression
Cellular hexose transport
HSP90 chaperone cycle for steroid hormone receptors (SHR)
RET signaling
Antimicrobial peptides
Phase II - Conjugation of compounds
GABA receptor activation
Urea cycle
FOXO-mediated transcription of cell cycle genes
HCMV Infection
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
GP1b-IX-V activation signalling
Interleukin-3, Interleukin-5 and GM-CSF signaling
Nucleosome assembly
tRNA Aminoacylation
Prolactin receptor signaling
GABA synthesis, release, reuptake and degradation
Cytosolic iron-sulfur cluster assembly
Signaling by NOTCH2
MyD88-independent TLR4 cascade
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Mitochondrial biogenesis
TP53 Regulates Metabolic Genes
Toll Like Receptor 3 (TLR3) Cascade
Synthesis of wybutosine at G37 of tRNA(Phe)
trans-Golgi Network Vesicle Budding
tRNA modification in the mitochondrion
Lysosomal oligosaccharide catabolism
TP53 Regulates Transcription of Cell Death Genes
Regulation of TP53 Expression and Degradation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Regulation of TP53 Activity through Acetylation
rRNA modification in the nucleus and cytosol
Carboxyterminal post-translational modifications of tubulin
Nucleotide salvage
NGF processing
PI3K Cascade
OAS antiviral response
FCGR3A-mediated phagocytosis
Lysine catabolism
EGR2 and SOX10-mediated initiation of Schwann cell myelination
Signaling by SCF-KIT
TCF dependent signaling in response to WNT
ABC-family proteins mediated transport
Latent infection of Homo sapiens with Mycobacterium tuberculosis
Amino acid synthesis and interconversion (transamination)
G alpha (s) signalling events
Interleukin-1 family signaling
Signaling by NTRK1 (TRKA)
Signaling by NODAL
Collagen biosynthesis and modifying enzymes
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Signaling by BMP
Degradation of the extracellular matrix
Cytosolic sensors of pathogen-associated DNA
Caspase activation via Dependence Receptors in the absence of ligand
Miscellaneous transport and binding events
RHO GTPases activate IQGAPs
Signaling by Leptin
Regulated Necrosis
LGI-ADAM interactions
Synthesis, secretion, and deacylation of Ghrelin
Regulation of beta-cell development
Beta-catenin independent WNT signaling
Cargo concentration in the ER
FasL/ CD95L signaling
Major pathway of rRNA processing in the nucleolus and cytosol
Neutrophil degranulation
Synaptic adhesion-like molecules
RAB geranylgeranylation
Transcriptional regulation by RUNX1
Interleukin-6 family signaling
Signaling by Retinoic Acid
Integrin signaling
Serine biosynthesis
COPI-mediated anterograde transport
Late endosomal microautophagy
Effects of PIP2 hydrolysis
Platelet Adhesion to exposed collagen
DDX58/IFIH1-mediated induction of interferon-alpha/beta
RNA Polymerase II Transcription
Signaling by VEGF
Transmission across Electrical Synapses
Mitotic Prophase
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Peptide hormone biosynthesis
Fcgamma receptor (FCGR) dependent phagocytosis
S Phase
Degradation of beta-catenin by the destruction complex
SUMOylation of DNA damage response and repair proteins
RHO GTPases activate PKNs
Melanin biosynthesis
Surfactant metabolism
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
tRNA processing in the mitochondrion
Receptor-type tyrosine-protein phosphatases
Carnitine metabolism
Nucleobase biosynthesis
Mitochondrial calcium ion transport
Protein ubiquitination
ESR-mediated signaling
Biosynthesis of DPA-derived SPMs
Transcriptional regulation of granulopoiesis
Amino acids regulate mTORC1
FLT3 Signaling
Costimulation by the CD28 family
Factors involved in megakaryocyte development and platelet production
Processing of Capped Intronless Pre-mRNA
Signaling by NOTCH3
RAF/MAP kinase cascade
Energy dependent regulation of mTOR by LKB1-AMPK
ATF4 activates genes in response to endoplasmic reticulum  stress
Fc epsilon receptor (FCERI) signaling
Pre-NOTCH Expression and Processing
SUMOylation of chromatin organization proteins
Interleukin-10 signaling
Protein methylation
Reelin signalling pathway
Ketone body metabolism
Transcriptional regulation by RUNX2
Class A/1 (Rhodopsin-like receptors)
Transcriptional Regulation by MECP2
Generic Transcription Pathway
GPVI-mediated activation cascade
Neurotoxicity of clostridium toxins
Elastic fibre formation
Influenza Infection
DAP12 interactions
Trafficking and processing of endosomal TLR
Toll-like Receptor Cascades
Hedgehog 'on' state
O-linked glycosylation
C-type lectin receptors (CLRs)
RHO GTPases Activate WASPs and WAVEs
Senescence-Associated Secretory Phenotype (SASP)
Glyoxylate metabolism and glycine degradation
SUMOylation of DNA replication proteins
Intra-Golgi and retrograde Golgi-to-ER traffic
Intracellular oxygen transport
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Processing of SMDT1
Signaling by NTRK3 (TRKC)
Metabolism of cofactors
Cell recruitment (pro-inflammatory response)
Cholesterol biosynthesis
Signal regulatory protein family interactions
Thrombin signalling through proteinase activated receptors (PARs)
Transport of bile salts and organic acids, metal ions and amine compounds
YAP1- and WWTR1 (TAZ)-stimulated gene expression
Reversible hydration of carbon dioxide
Sphingolipid metabolism
Mitochondrial translation
Uptake and function of diphtheria toxin
Oxidative Stress Induced Senescence
Nonhomologous End-Joining (NHEJ)
SUMOylation of RNA binding proteins
Regulation of TP53 Activity through Association with Co-factors
Smooth Muscle Contraction
RNA polymerase II transcribes snRNA genes
E3 ubiquitin ligases ubiquitinate target proteins
Cargo recognition for clathrin-mediated endocytosis
Nicotinate metabolism
Regulation of mitotic cell cycle
Vitamin E
Transcriptional Regulation by E2F6
Class B/2 (Secretin family receptors)
Signaling by NTRK2 (TRKB)
Biosynthesis of DHA-derived SPMs
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives
SUMOylation of transcription cofactors
DNA Replication Pre-Initiation
Assembly and cell surface presentation of NMDA receptors
Signaling by FGFR4
Host Interactions with Influenza Factors
The citric acid (TCA) cycle and respiratory electron transport
Intrinsic Pathway for Apoptosis
mRNA Capping
Post-translational modification: synthesis of GPI-anchored proteins
Arachidonic acid metabolism
Gastrin-CREB signalling pathway via PKC and MAPK
Potassium Channels
Nonsense-Mediated Decay (NMD)
Signaling by Hippo
Signaling by NOTCH4
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
Incretin synthesis, secretion, and inactivation
Glycerophospholipid biosynthesis
MyD88 cascade initiated on plasma membrane
Branched-chain amino acid catabolism
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Selenoamino acid metabolism
Metabolism of vitamin K
SUMOylation of transcription factors
Intestinal absorption
Chromatin organization
Cristae formation
Lactose synthesis
RNA Polymerase III Transcription
SUMOylation of immune response proteins
Acetylcholine binding and downstream events
Signaling by Erythropoietin
Alpha-protein kinase 1 signaling pathway
Response of EIF2AK1 (HRI) to heme deficiency
Phenylalanine and tyrosine metabolism
FOXO-mediated transcription
SUMO E3 ligases SUMOylate target proteins
Presynaptic depolarization and calcium channel opening
Metabolism of porphyrins
Processing of Capped Intron-Containing Pre-mRNA
Protein folding
Mitotic Prometaphase
Erythrocytes take up oxygen and release carbon dioxide
Activation of gene expression by SREBF (SREBP)
Signaling by the B Cell Receptor (BCR)
Transcriptional regulation of white adipocyte differentiation
Gamma carboxylation, hypusine formation and arylsulfatase activation
Signaling by FGFR1
Gene Silencing by RNA
TP53 Regulates Transcription of Cell Cycle Genes
Interleukin-20 family signaling
MTF1 activates gene expression
Interleukin-4 and Interleukin-13 signaling
Post-translational protein phosphorylation
SUMOylation of intracellular receptors
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Interleukin-1 processing
mRNA Editing
Transport of vitamins, nucleosides, and related molecules
Regulation of cholesterol biosynthesis by SREBP (SREBF)
MAP kinase activation
NoRC negatively regulates rRNA expression
Aflatoxin activation and detoxification
DNA methylation
RHO GTPases Activate NADPH Oxidases
Metabolism of polyamines
Class I MHC mediated antigen processing & presentation
Signaling by MST1
Retinoid metabolism and transport
Pentose phosphate pathway
Formation of xylulose-5-phosphate
Chaperone Mediated Autophagy
Alanine metabolism
FOXO-mediated transcription of cell death genes
Cell surface interactions at the vascular wall
Interferon gamma signaling
L1CAM interactions
Metabolism of nitric oxide: NOS3 activation and regulation
Passive transport by Aquaporins
Peroxisomal lipid metabolism
Rap1 signalling
Response to elevated platelet cytosolic Ca2+
HIV Life Cycle
ISG15 antiviral mechanism
Signaling by TGF-beta Receptor Complex
Mitotic Telophase/Cytokinesis
Translocation of SLC2A4 (GLUT4) to the plasma membrane
RORA activates gene expression
Regulation of TP53 Activity through Phosphorylation
PTEN Regulation
RNA Polymerase I Transcription
Phase I - Functionalization of compounds
Cilium Assembly
G alpha (z) signalling events
Extra-nuclear estrogen signaling
Interferon alpha/beta signaling
MAPK targets/ Nuclear events mediated by MAP kinases
TCR signaling
Telomere Maintenance
Nucleotide Excision Repair
PIP3 activates AKT signaling
SRP-dependent cotranslational protein targeting to membrane
Activation of Matrix Metalloproteinases
Binding and Uptake of Ligands by Scavenger Receptors
Regulation of lipid metabolism by PPARalpha
Assembly of collagen fibrils and other multimeric structures
TNFs bind their physiological receptors
BMAL1:CLOCK,NPAS2 activates circadian gene expression
NR1D1 (REV-ERBA) represses gene expression
Cellular response to heat stress
NIK-->noncanonical NF-kB signaling
rRNA processing
Mitochondrial Fatty Acid Beta-Oxidation
Transcription from mitochondrial promoters
Nucleobase catabolism
Interleukin-12 family signaling
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Histidine catabolism
Signaling by PDGF
Sulfur amino acid metabolism
Plasmalogen biosynthesis
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation