• http://rdf.wikipathways.org/Pathway/WP2583_r135033/DataNode/d4781
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    • http://rdf.wikipathways.org/Pathway/WP2583_r135033/Comment/6cbd25ca313ceec88ca569f31e7e7fb2
• http://rdf.wikipathways.org/Pathway/WP2583_r135033/Comment/6cbd25ca313ceec88ca569f31e7e7fb2
  • http://www.w3.org/1999/02/22-rdf-syntax-ns#type
    • http://vocabularies.wikipathways.org/gpml#Comment
  • http://purl.org/dc/terms/isPartOf
    • http://rdf.wikipathways.org/Pathway/WP2583_r135033/DataNode/d4781
  • http://vocabularies.wikipathways.org/gpml#commentText
    • SHP-1/2 are tyrosine phosphatases. Here, SHP removes phosphates from PIP3 reverting it back to PIP2. (reverses the work of tyrosine kinase P13K) SHP is recruited to the PD-1 cytoplasmic tail when PD-1 ITIMs are phosphorylated.