• http://rdf.wikipathways.org/Pathway/WP2583_r135033/DataNode/ed30d
  • http://vocabularies.wikipathways.org/gpml#hasComment
    • http://rdf.wikipathways.org/Pathway/WP2583_r135033/Comment/fb5b364c1b6a3ed778f39a9887305004
• http://rdf.wikipathways.org/Pathway/WP2583_r135033/Comment/fb5b364c1b6a3ed778f39a9887305004
  • http://www.w3.org/1999/02/22-rdf-syntax-ns#type
    • http://vocabularies.wikipathways.org/gpml#Comment
  • http://purl.org/dc/terms/isPartOf
    • http://rdf.wikipathways.org/Pathway/WP2583_r135033/DataNode/ed30d
  • http://vocabularies.wikipathways.org/gpml#commentText
    • CD28 is a co-stimulatory surface receptor. It bind B7-1 and B7-2. After CD28 binds its ligand, it is phosphorylated by Lck. The effect of this phosphorylation activates P13K to generate PIP3 which recruits Itk to the cell membrane where Lck can phosphorylate it. Then Itk-P can recruit PLC-g