15156153 Hes proteins associate with JAK2 and STAT3, and facilitate complex formation between JAK2 and STAT3, thus promoting STAT3 phosphorylation and activation.
15688010 Tkip also inhibited constitutive (DU145) and IL-6-induced (LNCaP) activation of STAT3, consistent with the fact that STAT3 activation is mediated by JAK2.
11708838 (Organ: heart, CellLineName: IPC) The results demonstrated extensive phosphorylation of JAK2 and STAT3 in the IPC hearts which was almost completely abolished by an inhibitor of JAK2, AG490.
15155836 (Organ: kidney, CellLineName: 293) Inhibition of c-Src and Janus kinase 2 and 3 activities abolished STAT3 activation induced by Galpha14QL, but no physical association between Galpha14QL and c-Src could be detected by coimmunoprecipitation.
15650183 (Organ: liver) Using a series of inhibitors and dominant negative mutants, we show that HCV-induced activation of STAT-3 is mediated by oxidative stress and influenced by the activation of cellular kinases, including p38 mitogen-activated protein kinase, JNK, JAK-2, and Src.
15151905 (Tissue: endothelial) IL-6 treatment increased the phosphorylation of JAK2, an upstream activator of STAT3.
10891587 (Organ: brain, Tissue: glia, CellType: neural) The PSD fraction also had a janus kinase 2 (Jak2)-like molecule, Jak2, believed to phosphorylate Stat3.