SPARQL | HTML5 RDFa and Microdata document
  • http://rdf.wikipathways.org/Pathway/WP3151_r122792/Comment/2deea60c0437d8ef52a7acc39c895d32
    • http://www.w3.org/1999/02/22-rdf-syntax-ns#type
      • http://vocabularies.wikipathways.org/gpml#Comment
    • http://purl.org/dc/terms/isPartOf
      • http://rdf.wikipathways.org/Pathway/WP3151_r122792/DataNode/b391c
    • http://vocabularies.wikipathways.org/gpml#commentText
      • ROCK I (alternatively called ROK ?) and ROCK II (also known as Rho kinase or ROK ?) were originally isolated as RhoA-GTP interacting proteins. The kinase domains of ROCK I and ROCK II are 92% identical, and so far there is no evidence that they phosphorylate different substrates. RhoA, RhoB, and RhoC associate with and activate ROCK but other GTP-binding proteins can be inhibitors, e.g. RhoE, Rad and Gem. PDK1 kinase promotes ROCK I activity not through phosphorylation but by blocking RhoE association. PLK1 can phosphorylate ROCK II and this enhances the effect of RhoA. Arachidonic acid can activate ROCK independently of Rho.
    • http://vocabularies.wikipathways.org/gpml#source
      • Reactome
  • http://rdf.wikipathways.org/Pathway/WP3151_r122792/DataNode/b391c
    • http://vocabularies.wikipathways.org/gpml#hasComment
      • http://rdf.wikipathways.org/Pathway/WP3151_r122792/Comment/2deea60c0437d8ef52a7acc39c895d32