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Active Rac1 associates directly with Plexin-A1 in the linker region separating Plexin-A1's cytoplasmic GAP domains. Rac1 association relieves an inhibitory intramolecular interaction between the two Plexin-A1 GAP domains C1 and C2.
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http://rdf.wikipathways.org/Pathway/WP3151_r122792/Comment/ab3241e8bad2349d96e0c1b31dea9830