SPARQL | HTML5 RDFa and Microdata document
  • http://rdf.wikipathways.org/Pathway/WP3217_r102616/Interaction/f5406
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  • http://rdf.wikipathways.org/Pathway/WP3217_r102616/Comment/6e98331822bcea170376f7a0e1d6975a
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      • Many Cl- channels such as CFTR, ClC, CaCC, and ligand-gated anion channels are permeable to bicarbonate (HCO3-) which is an important anion in the regulation of pH. Many tissues, including retinal pigment epithelium (RPE), utilize HCO3- transporters to mediate transport of HCO3-. Bestrophns 1-4 (BEST1-4, aka vitelliform macular dystrophy proteins) have high permeability to HCO3- (Hu & Hartzell 2008). Defective BEST1 may play a role in macular degeneration in the eye due to impaired HCO3- and Cl- conductance (Hu & Hartzell 2008).
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      • Reactome