10693929 (Tissue: cortex, CellType: neural, CellLineName: PC 12) PD098059 blocks activation of MEK1 by Raf (Dudley et al., 1995 ) and reduces NGF-induced differentiation in PC12 cells (Alessi et al., 1995 ; Pang et al., 1995 ), as well as BDNF-induced phosphorylation of extracellular signal-regulated kinase 2 in cortical neurons (Finkbeiner et al., 1997 ).
9885231 (CellType: leukocyte) In turn, Ras activates the serine/threonine kinase Raf. 11 Upon activation, Raf phosphorylates MEK1 and MEK2.