12730329 Two upstream dual specificity enzyme kinases MEK1/MEK2 (MAPKKs) phosphorylate threonine and tyrosine residues of ERK1/2 and initiate an ultrasensitive downstream phosphorylation cascade ( 25 ).
12496361 (Tissue: nerve, CellType: neural) Activated Ras associates with Raf that phosphorylates and activates the mitogen-activated protein (MAP) kinase kinases MEK1 and MEK2, which in turn phosphorylate the MAP kinases ERK1 and ERK2.
12832465 All together, these results indicated that MEK2 is not essential for cell proliferation and ERK1/ERK2 activation in response to mitogens.
12584202 Because MEK1/2 phosphorylates and activates p42/p44MAPK, the inhibitor would be expected to inhibit the phosphorylation of p42/p44MAPK and their downstream targets.
10650934 Cells were pretreated for 30 min with 10 ïÿý M PD98059, an inhibitor of MEK1 and -2, the MAPK kinases that are responsible for activation of ERK1 and -2.
11238126 (CellLineName: AML) MEK-1/2 activation correlated with ERK-1/2 activation in 7 of 14 AML cell lines and 2 of 5 CML cell lines.
9927426 (CellType: fibroblast, CellLineName: PC 12) Both p42 and p44MAPK are activated by dual phosphorylation on a threonine and a tyrosine residue, achieved by the dual-specificity kinase MKK1/2.
11983682 (Organ: hippocampal, CellType: neural) Hippocampal neurons were treated with UO126, an inhibitor of MEK1 and MEK2, which can activate ERK1 and ERK2.