11053438 (Tissue: serum) Activation of Transcription Factor Elk1 during Thapsigargin-induced pip92 Expression-- Previous studies have shown that serum response element (SRE ) present in the pip92 promoter can interact with recombinant serum response factor (SRF ) and Elk1 proteins forming a tertiary complex ( 16 , 25 ).
11839761 (Tissue: serum) When phosphorylated by ERK2, Elk-1 forms a complex with the serum response factor and binds the serum response promoter element to enhance transcription from the c- fos promoter.
10477597 Also, they phosphorylate Elk1, which interacts with the serum response factor and participates in c- fos activation (reviewed in Refs. 18 and 19 ).
12600988 First, it has been concluded from many transfection (permanent and transient) experiments that the serum response factor-ELK1 complex, likely also including the nearby AP-1 proteins, is required for the optimal transcriptional response to growth factors and to phorbol esters (TPA ).
11245588 The three MAP kinase pathways regulate AP-1 activity both by increasing the transcription of the jun and fos genes and by phosphorylation of newly synthesized AP-1 transcription complexes. c-Fos gene transcription is activated by the cooperative interaction of Elk-1 with the serum response factor (SRF).