12562867 Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II.
11895866 (CellLineName: A431) Silibinin inhibits constitutive activation of MAPK/ERK1/2 in A431 cells.
9395450 ERK1/2 has been shown to phosphorylate and activate pp90 rsk , leading to phosphorylation of S6 protein and increased protein synthesis.
14715266 (Tissue: marrow, CellType: osteoblast, CellLineName: CFU-O) H(2)O(2) treatment stimulated phospholipase C-gamma1 (PLC-gamma1), extracellular signal-regulated kinase 1/2 (ERK1/2), and NF-kappaB signaling but inhibited p38 mitogen-activated protein kinase (MAPK) activation.
9039124 (Organ: umbilical vein, Tissue: smooth muscle, CellLineName: RASMCs) To further confirm the specificity of these results implicating the MAPK pathway, an antisense oligodeoxynucleotide (ODN) directed against the initiation translation site of rat ERK-1 and ERK-2 mRNA was used to suppress MAP kinase synthesis and function in rat VSMCs.