Along with our findings that HIV-1 Tat induces HDAC6 expression in astrocytes, HIV-1 Tat may have a regulatory role in the expression of other HDACs.
HIV-1 Tat increased HDAC6 expression at both the mRNA and protein levels in primary mouse astrocytes
Collectively, our findings demonstrated that depletion of TDP-43 may protect RGC-5 cells against oxidative stress-mediated apoptosis and autophagy by suppressing its target HDAC6.