Endogenous AT3 coimmunoprecipitates with both dynein and HDAC6, and these immunoprecipitates contain ubiquitin protease activity (Fig. 3). These data are consistent with the function of AT3 with HDAC6 and dynein in the pathway responsible for trafficking aggregated proteins to form aggresomes.
Burnett et al. also found that ataxin-3 interacts with HDAC6 and dynein motor
NOTE: AT3 is an alias for ATXN3.