Further supporting a HDAC6–Hsp–tau complex, deletion of the SE14 domain in HDAC6 similarly reduced the binding of HDAC6 to Hsp70 and Hsc70 (Supplementary Fig. 1f).
HDAC6 co-aggregates with tau and accumulates in pathological tau lesions.
NOTE: HSP70 is an alias for HSPA4 and HSC70 is an alias for HSPA8.