cells and the human promonocytic cell line THP.1 demonstrated that endogenous HDAC6 coimmunoprecipitated with HDAC11 (Fig. 2A). Similarly, endogenous HDAC11 was coimmunoprecipitated by anti-HDAC6 antibody in primary peritoneal macrophages (Fig. 2B).
Co-expression of HDAC11, a class IV HDAC and HDAC6 interacting partner.
[from the second reference]: Here we report that another HDAC, HDAC6, primarily a cytoplasmic protein, associates with HDAC11 and modulates the expression of IL-10 as a transcriptional activator. To our knowledge, this is the first demonstration of two different HDACs being recruited to the same gene promoter to dictate divergent transcriptional responses.