We demonstrate that HDAC6 has the capacity to bind both polyubiquitinated misfolded proteins and dynein motors, thereby acting to recruit misfolded protein cargo to dynein motors for transport to aggresomes.
NOTE: There is a large family of Dynein motor proteins. The selected member here is DYNC1I2. The selection was made based on the material and method section of the original article referring to the anti-dyenin antibody (α-dynein (70.1, Sigma) which is raised against dynein intermediate chain family.According to NCBI there is only one member of the dynein family that represents intermediate chain.