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    • GSK3b was found to co-localize with HDAC6 in hippocampal neurons, and inhibition of GSK3b resulted in decreased binding of antibody to phosphoserine-22, a potential GSK3b phosphorylation site in HDAC6.. We also provide evidence that GSK3b may directly regulate HDAC6. [From the second reference]:Ketamine enhanced the direct interaction of GSK-3 with HDAC6.Co-IP of GSK-3 and HDAC6 in the vehicle and ketamine-treated SPNs showed that ketamine treatment enhanced the direct interaction.