OCT4B-190 downregulated GSK-3β activity and HDAC6 expression simultaneously.
Representative immunofluorescence images demonstrated the colocalization of OCT4B-190 (green), GSK-3 (blue) and HDAC6 (red) in primary neuronal cultures.
This study for the first time revealed novel biological functions of OCT4B-190 in the experimental stroke, with implications for targeting GSK-3 and HDAC6 simultaneously as a possible neuroprotective strategy.
NOTE:OCT4B is an alias for POU5F1.