11292831 (Organ: brain, CellLineName: PC12D) We next showed in coimmunoprecipitation experiments that CalDAG-GEFI forms a complex with Rap1 and B-Raf following exposure to carbachol or calcium ionophore and the DAG analogue OAG (Fig. 8 ).
9789079 (CellLineName: 293T) Expression of CalDAG-GEFI activates Rap1A and inhibits Ras-dependent activation of the Erk/MAP kinase cascade in 293T cells.
14702343 (CellLineName: JURKAT) Our results have demonstrated that forced expression of CalDAG-GEFI activated endogenous Rap1 and augmented adhesion to ICAM-1 in response to TCR stimulation.
10835426 (CellLineName: 293T) As reported previously ( 15 , 16 ), CalDAG-GEFI activated Rap1 and, to a lesser extent, R-Ras, and CalDAG-GEFII activated both Ha-Ras and R-Ras