10196191 In contrast, mutation of residue 70 does not affect the interaction of Cdc25 Mm with Rap1A and even increases the activity toward Ras(Q70L) almost 2-fold, indicating that residue 70 has an important role in the interaction with C3G but not as much with Cdc25 Mm .
15572660 (Tissue: endothelial) However, RasGRP2 is a Rap1 activator and not a Ras activator, whereas RasGRP3 is an activator of Ras and Rap1.
15213298 RasGRP3 activates both Ras and Rap1 (Yamashita et al., 2000 ), and RasGRP4 activates Ras (Reuther et al., 2002 ; Yang et al., 2002 ).