MedLine Reference 10024371:1025
Sentence Induction of the SRE occurs upon formation of a ternary complex with serum response factor, p62 TCF , and the SRE. 118 ERK1/2 was shown to phosphorylate p62 TCF (also known as elk-1 or SAP-1), resulting in enhanced ternary complex formation. 119 Thus, the SRE present in the c- fos promoter may be regulated by angiotensin II??????stimulated ERK1/2 phosphorylation of p62 TCF , as shown for EGF. 119 Activation of ERK1/2 requires activation of Ras and Raf, events that are regulated by tyrosine phosphorylation.
Journal J. Neurosci
Journal Reference v19 i5 p1876 (1999)
Journal Link http://www.blackwell-synergy.com/links/doi/10.1046/j.1471-4159.2002.01075.x/full/
Tissue fat
Organ liver
CellType eosinophil
CellLineName CWSV1
Source Ariadne Pathways
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MedLine Reference 11751459:1010
Sentence On bryo 1 treatment, the activity of ERK2 (p42) rapidly increased, with ERK1 (p44) protein levels remaining constant. p44/42 immunoprecipitates from lysates of bryo 1-treated cells had increased their ability to phosphorylate the transcription factor Elk-1.
Journal Cell Growth and Diff
Journal Reference v12 i12 p641 (2001)
Journal Link http://cgd.aacrjournals.org/cgi/content/full/12/12/641
Tissue lymph
CellLineName reh
Source Ariadne Pathways
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MedLine Reference 11782488:1286
Sentence It was also reported that BMK1 activation is required for neurotrophin stimulation of MEF2C in both cortical neurons and PC12 cells, distinct from ERK1/2-induced activation of Elk1 and CREB transcription factors ( 30 ).
Journal J. Biol. Chem
Journal Reference v277 i11 p9614 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/11/9614
Tissue cortex
CellType neural
CellLineName PC 12
Source Ariadne Pathways
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MedLine Reference 11297525:1051
Sentence In addition, the activation of ERK1/2 correlated with increased activation of the downstream transcription factor Elk-1.
Journal J. Biol. Chem
Journal Reference v276 i18 p15537 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/18/15537
Tissue marrow
Source Ariadne Pathways
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MedLine Reference 12032150:1015
Sentence In the nucleus, activated ERK1/2 continuously phosphorylate Elk-1, leading to the prolonged expression of c- fos , which results in the expression of several genes such as matrix metalloproteinase (mmp)-9 ; MMP-9 activity is required for the induction of the cell motility response.
Journal J. Biol. Chem
Journal Reference v277 i31 p28256 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/31/28256
Organ kidney
CellLineName Madin Darby
Source Ariadne Pathways
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MedLine Reference 9020136:1065
Sentence Likewise GST-Sap, the GST fusion protein containing the C-terminal activation domain of Elk-1 was more readily phosphorylated by ERK-1 than by JNK-1 in vitro (Fig. 1 A , lower right panel ), although this difference was not as pronounced as with GST-Sap. -- Fig. 1.
Journal J. Biol. Chem
Journal Reference v272 i7 p4219 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/7/4219
Source Ariadne Pathways
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MedLine Reference 11408617:1037
Sentence Once activated, ERK1/2 can phosphorylate a ternary complex factor, Elk-1, that further interacts with serum response factor and induces the transcription of c-fos through serum-responsive element (Karin, 1995 ).
Journal Mol. Pharm
Journal Reference v60 i1 p217 (2001)
Journal Link http://molpharm.aspetjournals.org/cgi/content/full/60/1/217
Source Ariadne Pathways
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MedLine Reference 12239223:1248
Sentence ERK1/2 then activates transcription factor ELK-1, whereas JNK and p38 MAPK activate ATF2 .
Journal J. Biol. Chem
Journal Reference v277 i50 p48755 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/50/48755
Source Ariadne Pathways
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MedLine Reference 11463794:1190
Sentence A, phosphorylation of Elk1 by HA-ERK1 and HA-ERK1b.
Journal J. Biol. Chem
Journal Reference v276 i38 p35280 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/38/35280
CellLineName COS-7
Source Ariadne Pathways
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MedLine Reference 12498787:4
Sentence Since Erk1 and Erk2 regulate transcription from the Fos serum response element (SRE) by phosphorylating the ternary complex factors Elk-1 and SAP-1 ( Treisman, 1995 ), we examined the effect of integrin ligation on the Fos SRE.
Journal Renal Phys
Journal Reference v276 i29 p26814 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/29/26814
Source Ariadne Pathways