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    • MedLine Reference 10625698:1034 Sentence Activated MAPK interacts with a number of downstream targets, including the p90 ribosomal S6 kinase (p90 Rsk ) ( 19 ) and MAPK-activated protein kinase-2 (MAPKAP-K2 ) ( 20 , 21 ), which are activated by ERK1/2 and p38 MAPK , respectively. Journal J. Biol. Chem Journal Reference v275 i2 p1457 (2000) Journal Link http://www.jbc.org/cgi/content/full/275/2/1457 Organ ventricle CellType myocyte Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 8846784:6 Sentence In contrast, full-length GST-MAPKAP kinase-2 was phosphorylated at Thr25 (and not activated) by p42 MAPK, suggesting a role for the N-terminal domain in specifying activation by RK in vivo. CellLineName KB Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 14499342:7 Sentence ERK phosphorylated MK2 in vitro and activated MK2 in f-methionyl-leucyl-phenylalanine (FMLP)-stimulated neutrophils. CellType neutrophil Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 8900202:1138 Sentence MBP is an efficient substrate for ERK1 and ERK2, whereas GST-cJun (1-169) includes the activating phosphorylation sites Ser-63 and Ser-73, which have been shown to be phosphorylated by SAPK/JNK but not by ERK1, ERK2, or p38 HOG1 ( 3 ). 2 Similarly, hsp27 is an efficient substrate for MAPKAPK2, which in turn is predominantly activated by p38 HOG1, although MAPKAPK2 can also be phosphorylated in vitro by ERK1 and ERK2 ( 29 , 30 ). -- Fig. 2. Journal J. Biol. Chem Journal Reference v271 i43 p27107 (1996) Journal Link http://www.jbc.org/cgi/content/full/271/43/27107 CellLineName Pam 212 Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 8798679:1021 Sentence Although p42 MAPK can also phosphorylate and activate MAPKAP kinase-2 in vitro , the MAPK pathway is not activated by these stresses; conversely, activation of the MAPK pathway is not associated with activation of MAPKAP kinase-2 ( 9 , 11 ). Journal J. Biol. Chem Journal Reference v271 i40 p24313 (1996) Journal Link http://www.jbc.org/cgi/content/full/271/40/24313 Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 10022874:1302 Sentence The MAP kinase-activated protein kinases, Rsk and MAPKAPK-2, are similarly phosphorylated in their T loops by ERK and p38, respectively ( 2 , 8 ). Journal Mol. Cell. Biol Journal Reference v19 i3 p1871 (1999) Journal Link http://mcb.asm.org/cgi/content/full/19/3/1871 Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 12649327:1050 Sentence Both ERK and p38 can phosphorylate CREB via several downstream kinases including MSK1 for ERK and p38, p90RSK for ERK, and MAPKAPK2 for p38 ( 12 , 14 , 26 ). Journal Mol. Endocrin Journal Reference v17 i6 p1131 (2003) Journal Link http://mend.endojournals.org/cgi/content/full/17/6/1131 Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 14688255:1134 Sentence This co-expression system was used previously in our laboratory to activate GST-RSK CTD ( 21 ), and ERK2 has been reported to activate MK2 ( 26 ). Journal J. Biol. Chem Journal Reference v279 i11 p10176 (2004) Journal Link http://www.jbc.org/cgi/content/full/279/11/10176 Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 8995385:1254 Sentence First, LY294002, which inhibited Erk-1 and 2 but not p38, failed to inhibit MAPKAPK-2. Journal J. Biol. Chem Journal Reference v272 i2 p937 (1997) Journal Link http://www.jbc.org/cgi/content/full/272/2/937 CellType leukocyte Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 11463795:1195 Sentence With respect to alternative non-PLD/PA mechanisms whereby ERK could conceivably activate PKC-eta/ , it has been reported that ERK-activated MAPK-activated kinase-2 ( 34 , 35 ) and MSK-1 ( 36 ) can act like PDK-1 and/or PDK-2 and phosphorylate PKB on serine 308 and threonine 473 residues. Journal J. Biol. Chem Journal Reference v276 i38 p35537 (2001) Journal Link http://www.jbc.org/cgi/content/full/276/38/35537 Tissue skeletal muscle CellType adipocyte Source Ariadne Pathways
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