11274965 We compared the effects of oxidizing reagents, in particular thimerosal, and of cyclic ADP-ribose (cADPR) on IP3 binding to the various IP3R isoforms.
8633244 IP3 activates the IP3 receptor (IP3R), an intracellular calcium release channel on the endoplasmic reticulum.
9688849 Thus, besides affecting the binding of IP3 to IP3R ( 49 , 50 ), the effects of Mg2+ on the single-channel properties of the IP3R may therefore contribute to the control of temporal and spatial patterns of Ca2+ release from intracellular stores.
11017917 (CellType: myocyte) IP3 releases Ca2+ from intracellular stores by opening specific Ca2+ channels (IP3R).
12621039 (Organ: cerebellar, CellType: Brain Stem, CellLineName: ng108-15) It has been reported that IP3 binding to the IP3R is not cooperative ( 31 , 33 ), and the same property holds true for the wild-type receptor and all of the mutant receptors except D1-223 expressed in R23-11 cells (Table I ).