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    • -------------------------------------------------------------------------------- MedLine Reference 11454682:1161 Sentence Activated ERK1/2 phosphorylated Elk-1, which involves in the induction of the growth-related genes, suggesting that stimulative effects of low-dose irradiation were mediated by ERK1/2 activation. Journal Cancer Res Journal Reference v61 i14 p5396 (2001) Journal Link http://cancerres.aacrjournals.org/cgi/content/full/61/14/5396 Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 10444401:1223 Sentence Once in the nucleus, ERK can phosphorylate and activate transcription factors such as TCF/ELK-1, resulting in c-Fos production and AP-1 complex formation ( 13 , 15 ). Journal Cell Phys Journal Reference v277 i2 pC253 (1999) Journal Link http://ajpcell.physiology.org/cgi/content/full/277/2/C253 Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 11090049:1273 Sentence Therefore, it has been proposed that Elk1-dependent gene activation can occur independently of SRE/SRF if it can bind to the promoter efficiently. 50 This proposition is supported by the finding that the phosphorylation of Elk1 by ERK2 increases its ability to bind to DNA without interacting with SRF 54 , 55 and by the fact that Elk1 binding is facilitated in transfection experiments with a reporter gene containing multiple high-affinity Elk1 binding sites 40 , 56 or phosphorylation in its C-terminus. 55 , 57 Even though the 9E3/cCAF promoter does not contain an SRE, Elk1 binds to the Elk1 elements and activates transcription, suggesting that thrombin-induced Elk1 activation does not require cooperation with SRF. Journal Blood Journal Reference v96 i12 p3696 (2000) Journal Link http://www.bloodjournal.org/cgi/content/full/96/12/3696 Tissue smooth muscle Organ umbilical vein CellType fibroblast Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 11812784:1038 Sentence Activated ERK1/2 phosphorylated Elk-1, which involves in the induction of the growth-related genes, suggesting that stimulative effects of low-dose irradiation were mediated by ERK1/2 activation. Journal EBM Journal Reference v277 i15 p12532 (2002) Journal Link http://www.blackwell-synergy.com/links/doi/10.1046/j.1471-4159.2002.01075.x/full/ Tissue stroma Organ renal CellType b cell CellLineName JEG3 Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 10463587:1029 Sentence MAP kinase (MAPK/ERK) phosphorylates Elk-1, which is part of the ternary complex factor that binds to the serum response element in the fos promotor; JNK phosphorylates c-Jun, Elk-1, and ATF-2; and p38 kinase phosphorylates both ternary-complex-factor /Elk-1 and ATF-2. Journal Cancer Res Journal Reference v59 i16 p3935 (1999) Journal Link http://cancerres.aacrjournals.org/cgi/content/full/59/16/3935 Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 11520792:1024 Sentence TCFs, such as Elk-1, Sap-1, and Fli-1, are targets of the MAPK pathway. 36 , 37 Our data indicated that phosphorylation of Elk-1 by the MEK-ERK1/2 pathway induces Egr-1 expression in LPS-stimulated monocytes and subsequent TF gene expression. Journal Blood Journal Reference v98 i5 p1429 (2001) Journal Link http://www.bloodjournal.org/cgi/content/full/98/5/1429 CellType monocyte Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 12495932:1207 Sentence In summary, this study has demonstrated, in a rat in vivo model, that both serpentine and amphibole asbestos fibers induced protracted phosphorylation of intrapulmonary ERK proteins and upregulated Elk-1 phosphorylation by ERK. Journal AJRCMB Journal Reference v28 i1 p51 (2003) Journal Link http://ajrcmb.atsjournals.org/cgi/content/full/28/1/51 Source Ariadne Pathways --------------------------------------------------------------------------------
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