9639556 MLK2 and MEKK1 also activated SKK2/MKK3 and SKK3/MKK6, the direct upstream activators of SAPK2a/p38.
9808624 MEKK1, however, was found to activate additional MAPKKs, including Jun amino (N)-terminal kinase kinase 1(MKK4) [JNKK1(MKK4)] (D?rijard et al. 1995 ; Lin et al. 1995 ), JNKK2(MKK7) (Wu et al. 1997 ), MKK3, and MKK6 (Stein et al. 1996 ).
11306453 In response to extracellular stimuli, MEKK1 is a strong activator of MKK4 and MKK7, and a weaker activator of MKK3 and MKK6 (Fig. 1 A ; Ref. 19 ).
12960165 (CellLineName: RAW264.7) In addition, MEKK1 can stimulate the p38 MAPK through phosphorylation of MKK3 and MKK6 ( 37 ).
11574474 (CellLineName: 293) D-MEKK1 was found to phosphorylate MKK6 efficiently in vitro .