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    • 11880369 Diacylglycerol has been shown to regulate RasGRP subcellular location and catalytic activity ( 8 , 15-17 ). 15879121 Y775 and Y783 are therefore identified as the primary regulatory tyrosines for both the IP 3 -mediated Ca 2+ flux and the DAG-mediated activation of the PKC/RasGRP pathway. 17492052 (CellType: platelet) We have recently identified Ca 2+ and diacylglycerol-regulated guanine nucleotide exchange factor I (CalDAG-GEFI; also referred to as RasGRP2) as crucial for ��Ω��ΩΩ��Ω��ΩΩΩ 3 integrin activation in platelets ( 15 ). 11395491 (CellType: t cell) IP 3 binds receptors that regulate the release of stored Ca 2+ , whereas DAG is required to activate proteins such as protein kinase C and Ras guanyl nucleotide releasing protein (RasGRP) ( 17-19 ). 15795236 (CellType: t cell) An increase in inositol ( 1 , 4 , 5 ) tris phosphate levels results in release of calcium from intracellular stores, whereas increased diacylglycerol results in stimulation of PKC and RasGRP (for review see reference 30 ). 11292831 (CellLineName: PC12D) Together, these data define a novel signaling pathway for M 1 mAChR , where increases in Ca 2+ and diacylglycerol stimulate the sequential activation of CalDAG-GEFI , Rap1, and B-Raf, resulting in the activation of MEK and ERK1/2. 14532295 (CellType: b cell, CellLineName: ramos) Conversely, diacylglycerol both activates RasGRP1 and causes the activation and translocation of diacylglycerol kinase, which abrogates the activation of the GRP protein ( 43 , 44 ). 14557275 (CellLineName: MOCK) In this regard, it has been reported that DAG kinase zeta phosphorylates specifically localized DAG molecules, thereby controlling the activation of the DAG-activated signaling protein RasGRP and H-Ras ( 20 ). 11257115 (CellLineName: Rat2) It is important then that cells regulate the DAG that activates RasGRP. 11352924 (Organ: brain) DAG produced in response to these external stimuli activates PKC and the guanine nucleotide exchange factors vav and RasGRP ( 39 , 40 ).
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