11035106 (Tissue: alveola, CellType: macrophage) We then evaluated whether or not PDK-1 might be involved in PKC activation by examining complex formation.
12169624 Interestingly, however, PDK1 can only interact with full-length PKC when it is not phosphorylated at its hydrophobic motif and phosphorylation of this motif was shown to somehow mask this region, preventing it from interacting with PDK1 ( Gao et al ., 2001 ).
11500364 Furthermore, the data appear to exclude a role for members of the PKC family that are also regulated by PDK1 in the regulation of 4E-BP1 phosphorylation: an earlier report indicated a role in this for PKCdelta ( Kumar et al ., 2000 ).
10330161 (CellLineName: PC 12) Very recently, PKCdelta ( 27 ) and PKCeta ( 5 , 27 ) have been shown to be activated by a wortmannin-sensitive, PI-3-kinase-dependent pathway via phosphorylation of PKC by PDK1.
11376011 To probe whether the interaction of protein kinase C with PDK-1 was direct or mediated by a scaffold protein, we examined the interaction of pure PDK-1 with pure protein kinase C.
11971024 Complicating the picture, the PIP 3 -dependent PDK1, besides playing a critical role in activating PKB, has also been shown to phosphorylate/activate various PKC isoforms ( 27 , 28 , 29 ).
10438924 Recent work has shown that PDK1 phosphorylates and activates the p70 S6K kinase ( 86 ), the Sgk protein kinase ( 87 ), and the isoform of protein kinase C (PKC) ( 88 ).
10744767 In this communication, we addressed whether the phosphorylation of protein kinase C by PDK-1 is conformationally regulated.
10861044 PDK-1 has been shown to phosphorylate/activate various PKC isoforms ( 24 , 25 , 26 , 27 , 28 ).