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    • MedLine Reference 11983682:1198 Sentence Hippocampal neurons were treated with UO126, an inhibitor of MEK1 and MEK2, which can activate ERK1 and ERK2. Journal J. Biol. Chem Journal Reference v277 i27 p24676 (2002) Journal Link http://www.jbc.org/cgi/content/full/277/27/24676 Organ hippocampal CellType neural Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 9927426:1014 Sentence Both p42 and p44MAPK are activated by dual phosphorylation on a threonine and a tyrosine residue, achieved by the dual-specificity kinase MKK1/2. Journal EMBO Journal Reference v18 i3 p664 (1999) Journal Link http://embojournal.npgjournals.com/cgi/content/full/18/3/664 CellType fibroblast CellLineName PC 12 Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 11238126:1108 Sentence MEK-1/2 activation correlated with ERK-1/2 activation in 7 of 14 AML cell lines and 2 of 5 CML cell lines. Journal Blood Journal Reference v97 i6 p1823 (2001) Journal Link http://www.bloodjournal.org/cgi/content/full/97/6/1823 CellLineName AML Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 10650934:1110 Sentence Cells were pretreated for 30 min with 10 � M PD98059, an inhibitor of MEK1 and -2, the MAPK kinases that are responsible for activation of ERK1 and -2. Journal Endocrinology Journal Reference v141 i2 p544 (2000) Journal Link http://endo.endojournals.org/cgi/content/full/141/2/544 Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 12584202:1152 Sentence Because MEK1/2 phosphorylates and activates p42/p44MAPK, the inhibitor would be expected to inhibit the phosphorylation of p42/p44MAPK and their downstream targets. Journal J. Biol. Chem Journal Reference v278 i17 p14753 (2003) Journal Link http://www.jbc.org/cgi/content/full/278/17/14753 Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 12832465:1147 Sentence All together, these results indicated that MEK2 is not essential for cell proliferation and ERK1/ERK2 activation in response to mitogens. Journal Mol. Cell. Biol Journal Reference v23 i14 p4778 (2003) Journal Link http://mcb.asm.org/cgi/content/full/23/14/4778 Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 11080204:1217 Sentence Activated Raf phosphorylates the MAP kinase kinases MEK1 and MEK2, which subsequently activate ERK1 and ERK2. Journal J. Neurochem Journal Reference v75 i6 p2511 (2000) Journal Link http://www.blackwell-synergy.com/servlet/useragent?func=showIssues&code=jnc CellType fibroblast CellLineName PC12-E2 Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 12242299:1278 Sentence Neither LY-294002 nor wortmannin significantly affected the phosphorylation of ERK1/2 or MKK1/2 (Fig. 9A ), indicating that ERK activation is not controlled by PI3K signaling. Journal Mol. Cell. Biol Journal Reference v22 i20 p7226 (2002) Journal Link http://mcb.asm.org/cgi/content/full/22/20/7226 CellLineName HeLa Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 12730329:1047 Sentence Two upstream dual specificity enzyme kinases MEK1/MEK2 (MAPKKs) phosphorylate threonine and tyrosine residues of ERK1/2 and initiate an ultrasensitive downstream phosphorylation cascade ( 25 ). Journal Mol. Endocrin Journal Reference v17 i8 p1593 (2003) Journal Link http://mend.endojournals.org/cgi/content/full/17/8/1593 Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 12496361:1025 Sentence Activated Ras associates with Raf that phosphorylates and activates the mitogen-activated protein (MAP) kinase kinases MEK1 and MEK2, which in turn phosphorylate the MAP kinases ERK1 and ERK2. Journal Mol. Cancer Res Journal Reference v1 i2 p147 (2002) Journal Link http://mcr.aacrjournals.org/cgi/content/full/1/2/147 Tissue nerve CellType neural Source Ariadne Pathways
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