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    • MedLine Reference 11238126:1108 Sentence MEK-1/2 activation correlated with ERK-1/2 activation in 7 of 14 AML cell lines and 2 of 5 CML cell lines. Journal Blood Journal Reference v97 i6 p1823 (2001) Journal Link http://www.bloodjournal.org/cgi/content/full/97/6/1823 CellLineName AML Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 10650934:1110 Sentence Cells were pretreated for 30 min with 10 � M PD98059, an inhibitor of MEK1 and -2, the MAPK kinases that are responsible for activation of ERK1 and -2. Journal Endocrinology Journal Reference v141 i2 p544 (2000) Journal Link http://endo.endojournals.org/cgi/content/full/141/2/544 Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 11108712:1201 Sentence Finally, because MEK1 and MEK2 activate ERK , we assayed for ERK activity in the presence of the MEK inhibitor PD 98059 (Fig. 6 D ). Journal J. Biol. Chem Journal Reference v276 i10 p7586 (2001) Journal Link http://www.jbc.org/cgi/content/full/276/10/7586 CellType osteoblast Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 10747974:1181 Sentence PD 98059 and U0126 specifically inhibit MEK1 and MEK2, the kinases that phosphorylate ERK, but have no effect on other kinases including SAPK/JNK ( 56 , 57 ). Journal J. Biol. Chem Journal Reference v275 i21 p16064 (2000) Journal Link http://www.jbc.org/cgi/content/full/275/21/16064 Tissue epithelia Organ gastric Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 12225966:1161 Sentence We have recently reported that inhibition of muscle MAPKK1/2 (MEK1/2) abolishes isoproterenol-stimulated NKCC activity and ERK1/2 phosphorylation ( 31 ). Journal Cell Phys Journal Reference v283 i4 pC1025 (2002) Journal Link http://ajpcell.physiology.org/cgi/content/full/283/4/C1025 Tissue muscle Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 12393899:1082 Sentence To inhibit the ERK1/2 pathway, we applied PD98059, an inhibitor of MKK1 and MKK2 ( 30 ), which are upstream kinases that phosphorylate and activate ERK1/2. Journal J. Biol. Chem Journal Reference v277 i51 p49577 (2002) Journal Link http://www.jbc.org/cgi/content/full/277/51/49577 Tissue cortex CellType neural Source Ariadne Pathways MedLine Reference 12839832:1143 Sentence U-0126 is a selective inhibitor of the MAPK kinase MEK1/2, which directly activates ERK1/2 ( 13 , 50 ). Journal Cell Phys Journal Reference v285 i5 pC1122 (2003) Journal Link http://ajpcell.physiology.org/cgi/content/full/285/5/C1122 Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 10891480:1248 Sentence In contrast to its effect on HA-MEK1, the kinase-inactive mutant PKCetaKR did not block MEK2E-induced HA-ERK2 activation (Fig. 5 C). Journal Mol. Cell. Biol Journal Reference v20 i15 p5392 (2000) Journal Link http://mcb.asm.org/cgi/content/full/20/15/5392 Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 12623839:1052 Sentence Mkk1 and Mkk2 phosphorylate Erk kinases in the Thr-Glu-Tyr motif; Mkk3, Mkk4, and Mkk6 phosphorylate p38 kinases in the Thr-Gly-Tyr motif, while Mkk4 and Mkk7 regulate dual phosphorylation of JNK kinases in the Thr-Pro-Tyr motif ( Table 2 ). Journal Blood Journal Reference v101 i12 p4667 (2003) Journal Link http://www.bloodjournal.org/cgi/content/full/101/12/4667 Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 11038347:1040 Sentence The specificity of MEK1/2 inhibition was achieved by using two different MEK inhibitors, and by the additional use of transdominant-negative mutants, which inhibit MEK/ERK activation. Journal J. Biol. Chem Journal Reference v275 i50 p38953 (2000) Journal Link http://www.jbc.org/cgi/content/full/275/50/38953 Source Ariadne Pathways
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