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    • -------------------------------------------------------------------------------- MedLine Reference 10428835:1222 Sentence PD98059 is a specific inhibitor for MKK1 and -2 ( 56 ), upstream kinases that phosphorylate and activate ERK ( 15 , 57 ). Journal J. Biol. Chem Journal Reference v274 i32 p22569 (1999) Journal Link http://www.jbc.org/cgi/content/full/274/32/22569 Tissue cortex CellType neural CellLineName DIV Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 12529254:1190 Sentence The present study provides direct evidence that the P2X7-R can mediate ERK1/2 activation through a cellular pathway that is dependent on intracellular and extracellular Ca2+, Pyk2, c-Src, PI 3-K, and MEK1/2. Journal Cell Phys Journal Reference v284 i2 pC571 (2003) Journal Link http://ajpcell.physiology.org/cgi/content/full/284/2/C571 CellType macrophage Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 10827000:1180 Sentence MEK1 activity was assayed in muscle protein by measuring the ability of MEK1 immune complexes to phosphorylate a recombinant kinase-inactive MAPK (p42MAPK). Journal Endocrin. Metabol Journal Reference v278 i6 pE992 (2000) Journal Link http://ajpendo.physiology.org/cgi/content/full/278/6/E992 Tissue muscle Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 12746434:1159 Sentence These activation kinetic data are consistent with the fact that ERK1/2 is specifically activated by MEK1/2. Journal J. Biol. Chem Journal Reference v278 i31 p29000 (2003) Journal Link http://www.jbc.org/cgi/content/full/278/31/29000 Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 9207092:1125 Sentence Control experiments demonstrated that ERK2 and p38alpha were activated by their cognate MAP kinase kinases, MKK1 and MKK6 (data not shown). Journal PNAS Journal Reference v94 i14 p7337 (1997) Journal Link http://www.pnas.org/cgi/content/full/94/14/7337 Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 10636870:1150 Sentence MEK1/2 inhibition prevents H 2 O 2 -mediated activation of ERK1/2 to a greater extent than activation of p90RSK. Journal J. Biol. Chem Journal Reference v275 i3 p1739 (2000) Journal Link http://www.jbc.org/cgi/content/full/275/3/1739 CellLineName JURKAT Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 11303030:1103 Sentence The closely related mammalian kinases, ERK1 and ERK2 (also called p44 and p42), are activated by the MEK1/2 kinases in response to mitogenic signals. Journal J. Biol. Chem Journal Reference v276 i24 p20805 (2001) Journal Link http://www.jbc.org/cgi/content/full/276/24/20805 Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 11571230:1117 Sentence Assessment of VES-induced differentiation after blockage of ERK1/2 activation by MEK1 using the chemical inhibitor PD 98059. Journal Cell Growth and Diff Journal Reference v12 i9 p471 (2001) Journal Link http://cgd.aacrjournals.org/cgi/content/full/12/9/471 Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 12226077:1214 Sentence Expression of dominant negative MEK1 significantly attenuates the bFGF-induced phosphorylation of ERK1/2 (Fig. 3 C , lane 4 on the bottom panel ). Journal J. Biol. Chem Journal Reference v277 i46 p44417 (2002) Journal Link http://www.jbc.org/cgi/content/full/277/46/44417 Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 12960148:1141 Sentence Furthermore, S100A1-mediated activation of ERK 1/2 could be prevented by preincubation with PD98095 (2-10 � M ) ( Fig. 6 B ), a specific inhibitor of MEK1 ( 26 , 27 ). Journal J. Biol. Chem Journal Reference v278 i48 p48404 (2003) Journal Link http://www.jbc.org/cgi/content/full/278/48/48404 Source Ariadne Pathways
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