10777559 Both Ras-GRF and Ras-GRP/CalDAG-GEFII activate Ras and R-Ras; therefore, these GEFs appear to have two pathways for activation of JNK .
12782630 Sos and RasGRP proteins are involved in linking the activation of membrane or cytoplasmic tyrosine kinases with the stimulation of Ras GTPases ( 8 ).
10807788 (CellType: t cell) Here we show that RasGRP, a Ras activator that contains calcium-binding EF hands and a DAG-binding domain, is expressed in T cells.
15604236 (CellType: keratinocyte) TPA may activate PLCe through Ras activation, which is mediated by RasGRP1, a TPA-regulated Ras-specific guanine nucleotide exchange factor (GEF) expressed in keratinocytes (13) .
12070163 (CellType: t cell) Activated RasGRP ( 34 , 35 ) and PKCeta ( 36 , 37 ) in turn stimulate the Ras-ERK-AP-1 and NFkappaB pathways, respectively.
14532295 (CellType: keratinocyte) This result suggests that, although RasGRP1 can directly activate Ras in response to phorbol esters, PKC is still required for the downstream stimulation of the Raf/MEK/ERK pathway.
17190838 (CellType: MAST) These data indicated that N-Ras is the Ras member that is activated by RasGRP1 in mast cells.
11395491 (CellLineName: JURKAT) Recent studies have demonstrated that overexpression of another exchange factor for Ras, RasGRP, can enhance TCR-Ras-Erk signaling and increase interleukin-2 production in Jurkat cells ( 18 ).
14970203 (CellLineName: WEHI 231) This could be due to synergy between RasGRP1-mediated Ras activation and parallel BCR-initiated signaling pathways not involving Ras activation.
11120810 (CellType: t cell, CellLineName: JURKAT) RasGRP can mediate Ras activation in response to TCR cross-linking in Jurkat T cells and RasGRP overexpression enhances TCR-mediated activation of ERK ( 23 ).