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    • MedLine Reference 10666409:1192 Sentence These data indicate that activation of MAPKAPK2, which is immediately downstream of p38 MAPK, is highly correlated with PC’s protection. Journal Circulation Res Journal Reference v272 i6 p3296 (1997) Journal Link http://circres.ahajournals.org/cgi/content/full/86/2/144 Organ immunologic CellType myocyte Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 9679149:1317 Sentence Therefore, the data are consistent with phosphorylation of MAPKAPK2 by p38-MAPK being essential for activation. Journal J. Cell Biol Journal Reference v142 i2 p523 (1998) Journal Link http://www.jcb.org/cgi/content/full/142/2/523 Organ heart CellType myocyte Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 10993748:1166 Sentence Thus, unlike other MAP kinases, p38 MAP kinase activates the MAPKAP kinase 2 ( 21 ). Journal Heart Circul Journal Reference v279 i3 pH901 (2000) Journal Link http://ajpheart.physiology.org/cgi/content/full/279/3/H901 Organ heart Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 9727040:11 Sentence These findings demonstrate that the activation of p38 MAP kinase is involved not only in response to stress, but also in physiological signaling by gastrointestinal hormones such as CCK, where activation of Gq-coupled receptors stimulates a cascade in which p38 MAP kinase activates MAP kinase-activated protein kinase-2, resulting in Hsp 27 phosphorylation. Journal J. Cell Biol Journal Reference v142 i2 p523 (1998) Journal Link http://www.jcb.org/cgi/content/full/142/2/523 Organ gastric CellType myocyte Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 14499342:1 Sentence MAPK-activated protein kinase-2 (MK2) is activated by p38 MAPK in human neutrophils. CellType neutrophil Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 10704466:1014 Sentence Therefore, these studies demonstrate that p38alpha is a major upstream activator of MAPKAP kinase 2 and a key component of the IL-1 signaling pathway. Journal J. Exp. Med Journal Reference v274 i25 p17491 (1999) Journal Link http://www.jem.org/cgi/content/full/191/5/859 CellType macrophage CellLineName ES Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 9759836:1135 Sentence Both MAPKAPK-2 and its recently identified homologue, MAPKAPK-3, are phosphorylated and activated by p38 MAPK in vivo ( 43 , 59 ). Journal J. Immunol Journal Reference v161 i7 p3225 (1998) Journal Link http://www.jimmunol.org/cgi/content/full/161/7/3225 CellType b cell Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 10066767:1186 Sentence Although p38-alpha phosphorylated MAPKAP kinase-2 significantly but not GST-c-Jun (Fig. 6 A ), p38-delta phosphorylated GST-c-Jun but not MAPKAP kinase-2 (Fig. 6 B ). Journal J. Biol. Chem Journal Reference v274 i11 p7095 (1999) Journal Link http://www.jbc.org/cgi/content/full/274/11/7095 CellLineName 293T Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 11490018:1219 Sentence MAPKAPK2, which was originally designated HSP25/27 kinase, is phosphorylated and activated by p38 MAPK ( 8 , 9 , 10 ). Journal J. Immunol Journal Reference v167 i4 p2298 (2001) Journal Link http://www.jimmunol.org/cgi/content/full/167/4/2298 CellType MAST Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 11859076:1323 Sentence SRF can be phosphorylated by pp90 rsk , a known effector of ERKs, CaM kinases II and IV, and the MAPKAP-2 (MK2), which is regulated by p38 MAPK ( 10 ). Journal J. Biol. Chem Journal Reference v277 i18 p15376 (2002) Journal Link http://www.jbc.org/cgi/content/full/277/18/15376 CellType t cell Source Ariadne Pathways
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