• http://rdf.wikipathways.org/Pathway/WP722._r125764/Comment/d6cfe9b5bcef40012cb71e8ba4046351
  • http://www.w3.org/1999/02/22-rdf-syntax-ns#type
    • http://vocabularies.wikipathways.org/gpml#Comment
  • http://purl.org/dc/terms/isPartOf
    • http://rdf.wikipathways.org/Pathway/WP722._r125764/Interaction/e614c
  • http://vocabularies.wikipathways.org/gpml#commentText
    • MedLine Reference 12896977:1200 Sentence Multiple p38 MAPK-dependent kinases such as MAPKAP kinase 2/3 have been shown to increase CREB phosphorylation in various cell types, including T-lymphocytes ( 36 , 49 A?A?A? 51 ). Journal Mol. Endocrin Journal Reference v278 i42 p41034 (2003) Journal Link http://www.jbc.org/cgi/content/full/278/42/41034 Tissue egg Organ heart CellType t cell CellLineName PC 12 Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 10488088:1234 Sentence We now demonstrate that IGF-I induces promoter activity of the bcl-2 gene through activation of CREB via a novel signaling pathway mediated by MAPK kinase 6/p38eta MAPK/MAPKAP-K3 (Fig. 8 ). Journal J. Biol. Chem Journal Reference v274 i39 p27529 (1999) Journal Link http://www.jbc.org/cgi/content/full/274/39/27529 Tissue cortex CellType neural Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 11328854:1137 Sentence Additionally, these immune complex kinase assays confirmed previous reports indicating that MAPKAPK-3 can directly phosphorylate CREB in vitro ( 12 , 26 ). Journal Mol. Endocrin Journal Reference v15 i5 p716 (2001) Journal Link http://mend.endojournals.org/cgi/content/full/15/5/716 Tissue egg Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 10781029:1082 Sentence Indeed, MK2 was shown to phosphorylate the nuclear transcription factors CREB as well as SRF ( 5 , 6 ) and to modulate their transcriptional activity. 3pK is also able to phosphorylate CREB in vitro and to interact with several nuclear proteins in vivo . 2 We used a human heart cDNA library and a kinase inactive version of 3pK as a bait, because wild-type 3pK autonomously led to the transactivation of the reporter genes. Journal J. Biol. Chem Journal Reference v275 i27 p20239 (2000) Journal Link http://www.jbc.org/cgi/content/full/275/27/20239 Organ heart Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 0:10240051 Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 10706690:1224 Sentence MAPKAP-K2, MAPKAP-K3, and PKA also phosphorylate CREB and ATF1 at Ser 133 and Ser 63 , respectively ( 2 ). Journal J. Immunol Journal Reference v164 i6 p3018 (2000) Journal Link http://www.jimmunol.org/cgi/content/full/164/6/3018 CellType macrophage Source Ariadne Pathways
• http://rdf.wikipathways.org/Pathway/WP722._r125764/Interaction/e614c
  • http://vocabularies.wikipathways.org/gpml#hasComment
    • http://rdf.wikipathways.org/Pathway/WP722._r125764/Comment/d6cfe9b5bcef40012cb71e8ba4046351