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    • MedLine Reference 10625698:1036 Sentence Activated MAPK interacts with a number of downstream targets, including the p90 ribosomal S6 kinase (p90 Rsk ) ( 19 ) and MAPK-activated protein kinase-2 (MAPKAP-K2 ) ( 20 , 21 ), which are activated by ERK1/2 and p38 MAPK , respectively. Journal J. Biol. Chem Journal Reference v275 i2 p1457 (2000) Journal Link http://www.jbc.org/cgi/content/full/275/2/1457 Organ ventricle CellType myocyte Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 7923353:0 Sentence MAPK-activated protein kinase-2 (MAPKAP kinase-2) is activated in vitro by the p42 and p44 isoforms of MAPK (p42/p44MAPK). Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 8900202:1138 Sentence MBP is an efficient substrate for ERK1 and ERK2, whereas GST-cJun (1-169) includes the activating phosphorylation sites Ser-63 and Ser-73, which have been shown to be phosphorylated by SAPK/JNK but not by ERK1, ERK2, or p38 HOG1 ( 3 ). 2 Similarly, hsp27 is an efficient substrate for MAPKAPK2, which in turn is predominantly activated by p38 HOG1, although MAPKAPK2 can also be phosphorylated in vitro by ERK1 and ERK2 ( 29 , 30 ). -- Fig. 2. Journal J. Biol. Chem Journal Reference v271 i43 p27107 (1996) Journal Link http://www.jbc.org/cgi/content/full/271/43/27107 CellLineName Pam 212 Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 7592979:1021 Sentence In this article we use a recombinant glutathione S -transferase (GST)-MAPKAP kinase 2-fusion protein and various mutants to study the mechanism of activation of MAPKAP kinase 2 by p44 (ERK1) and p38/40 (RK) in vitro . Journal J. Biol. Chem Journal Reference v270 i45 p27213 (1995) Journal Link http://www.jbc.org/cgi/content/full/270/45/27213 Source Ariadne Pathways -------------------------------------------------------------------------------- MedLine Reference 10753939:1120 Sentence The ERK1 and ERK2 activator, MEK1 , has also been observed to activate MAPKAPK2 ( 58 ). Journal J. Biol. Chem Journal Reference v275 i15 p11284 (2000) Journal Link http://www.jbc.org/cgi/content/full/275/15/11284 Source Ariadne Pathways
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