15774771
Early studies using heterologously expressed hSERTin HEK-293 cells showed that -PMA increased SERT phosphorylation with parallel decreases in the V max for uptake of 5-HT and surface SERT density (Qian et al., 1997; Ramamoorthy et al., 1998a).
18445122
In the absence of nNOS, SERT may remain at the cell surface or target the plasma membrane through a constitutive pathway and thus exhibit theobserved elevations in basal 5-HT transport activity.