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Here we show that pharmacological manipulation of the PI3K signaling pathway caused by hypoinsulinemic conditions or selective pharmacological inhibition/activation of PI3K dramatically regulates the ability of AMPH to evokeDAT-mediated DA release in the striatum, as determined byHSCA.
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C , D , Representative traces illustrating AMPH evoked DA release in hDAT cells (black) is blocked by 10 M MPH ( C )o r1 0 M cocaine ( D ), whereas 10 M AMPH blocks basal DA efflux in hDAT A559V cells (red) with no further reductions evident with addition of MPH or cocaine.