12810613 (Organ: heart) We have generated transgenic mice overexpressing the Gq-coupled 5-HT2B receptor specifically in heart.
12738797 (CellType: cardiomyocyte) Using cultured cardiomyocytes and 5-hydroxytryptamine (5-HT)2B-receptor knockout mice as an animal model of dilated cardiomyopathy, for the first time we show that serotonin via the Gq-coupled 5-HT2B-receptor protect cardiomyocytes against serum deprivation-induced apoptosis as manifested by DNA fragmentation, nuclear chromatin condensation, and TUNEL labeling.