11278709 PKA , PKC , CaM kinase, CK2 , MAPKAP kinase-2, p60 S6K , and p90 RSK have been reported to phosphorylate CREB .
11006268 It has been reported that MAPKAP kinase-2 phosphorylates CREB in response to fibroblast growth factor in neuroblastoma cells ( 45 ).
11123233 (CellLineName: P0) Furthermore, activation of MAPKAP kinase 2 results in activation of the transcriptional factor CREB ( 44 ) as well as HSP27 in human cells and HSP25 in bovine and murine cells ( 4 , 17 ).
9139689 (CellType: pre B) One of the downstream targets of p38 is the MAPKAP kinase-2, which can activate the transcription factors CREB and ATF-1 ( 18 ) and phosphorylate heat-shock protein hsp27 ( 19 , 20 ).
9422727 (CellLineName: 9L) Although it has been shown that MAPKAPK-2 phosphorylates CREB at Ser-133 in vitro ( 73 ), we did not observe an increase in phosphorylation of CREB by MAPKAPK-2 activated by OA HS.
10487749 MK2 phosphorylates the nuclear transcription factors CREB (Tan et al. , 1996 ; Iordanov et al. , 1997 ), ATF-1 (Tan et al. , 1996 ) and SRF (Heidenreich et al. , 1999 ), indicating a role in transcriptional regulation.
8887554 (CellLineName: sk-n-mc) We show that MAPKAP kinase-2 phosphorylates CREB at Ser133 in vitro, that the FGF- or stress-induced activation of MAPKAP kinase-2 and phosphorylation of CREB and ATF-1 are prevented by similar concentrations of the specific p38 MAP kinase inhibitor SB 203580, and that MAPKAP kinase-2 is the only detectable SB 203580-sensitive CREB kinase in SK-N-MC cell extracts.