7731720 However, there has been no evidence for a direct interaction between B-Raf and Mek-1.
12218141 (CellType: neutrophil) This is consistent with other findings that C5a causes the activation of Raf-1 and B-Raf, which are upstream stimulators of MEK-1 in human neutrophils, with a peak of activation at 5 min, followed by suppressed activation thereafter ( 38 ).
15153095 In addition, MEK1/2 can be activated by B-Raf, a neuron-enriched isoform of Raf, which is in turn activated by a cAMP-responsive Ras homologue called Rap-1 [ 41 ].
12351703 V., Calleja V., Scimeca J.-C., Filloux C., Calothy G. and Van Obberghen E. (1995) Regulation of the MAP kinases cascade in PC12 cells: B-Raf activates MEK-1 (MAP kinase or ERK kinase) and is inhibited by cAMP.
12167697 Reactions were immunoblotted as indicated. (B) The reactions were identical to those for panel A, except that recombinant WT-MEK1 activated by recombinant B-Raf in vitro was used to phosphorylate the immunoprecipitated ERKs.