9651336 Subtypes 5-HT 6 and 5-HT 7 couple to stimulation of adenylyl cyclases through G s and display high affinities for antipsychotic and antidepressant drugs.
16189297 The insensitivity of the high-affinity agonist binding of the human 5-HT 7 receptor to the destabilizing effect of guanine nucleotides (Alberts et al., 2001 ; Krobert et al., 2001 ) is another indication the 5-HT 7 receptor and Ga s protein form a tight complex.