SPARQL | HTML5 RDFa and Microdata document
http://rdf.wikipathways.org/Pathway/WP1114_r120486/Complex/a14ad http://rdf.wikipathways.org/Pathway/WP1114_r120486/Complex/c1468 http://rdf.wikipathways.org/Pathway/WP1114_r120486/Complex/ca16e http://rdf.wikipathways.org/Pathway/WP1114_r120486/ComplexBinding/a14ad http://rdf.wikipathways.org/Pathway/WP1114_r120486/ComplexBinding/c1468 http://rdf.wikipathways.org/Pathway/WP1114_r120486/ComplexBinding/ca16e http://rdf.wikipathways.org/Pathway/WP1114_r120486/WP/Interaction/a1601 http://rdf.wikipathways.org/Pathway/WP1114_r120486/WP/Interaction/a1755 http://rdf.wikipathways.org/Pathway/WP1114_r120486/WP/Interaction/a78d7 http://rdf.wikipathways.org/Pathway/WP1114_r120486/WP/Interaction/a91f9 http://rdf.wikipathways.org/Pathway/WP1114_r120486/WP/Interaction/ac085 http://rdf.wikipathways.org/Pathway/WP1114_r120486/WP/Interaction/ad5df http://rdf.wikipathways.org/Pathway/WP1114_r120486/WP/Interaction/ae7b0 http://rdf.wikipathways.org/Pathway/WP1114_r120486/WP/Interaction/b579c http://rdf.wikipathways.org/Pathway/WP1114_r120486/WP/Interaction/b8414 http://rdf.wikipathways.org/Pathway/WP1114_r120486/WP/Interaction/b8ee0 http://rdf.wikipathways.org/Pathway/WP1114_r120486/WP/Interaction/b93cb http://rdf.wikipathways.org/Pathway/WP1114_r120486/WP/Interaction/b9d46 http://rdf.wikipathways.org/Pathway/WP1114_r120486/WP/Interaction/bbc67 http://rdf.wikipathways.org/Pathway/WP1114_r120486/WP/Interaction/bea51 http://rdf.wikipathways.org/Pathway/WP1114_r120486/WP/Interaction/c0f19 http://rdf.wikipathways.org/Pathway/WP1114_r120486/WP/Interaction/c377d http://rdf.wikipathways.org/Pathway/WP1114_r120486/WP/Interaction/c7324 http://rdf.wikipathways.org/Pathway/WP1114_r120486/WP/Interaction/c9fb0 http://rdf.wikipathways.org/Pathway/WP1114_r120486/WP/Interaction/c9fe0 http://rdf.wikipathways.org/Pathway/WP1114_r120486/WP/Interaction/cb2f0 http://rdf.wikipathways.org/Pathway/WP1114_r120486/WP/Interaction/d0e5f http://rdf.wikipathways.org/Pathway/WP1114_r120486/WP/Interaction/d6191 http://rdf.wikipathways.org/Pathway/WP1114_r120486/WP/Interaction/d8923 http://rdf.wikipathways.org/Pathway/WP1114_r120486/WP/Interaction/d991e http://rdf.wikipathways.org/Pathway/WP1114_r120486/WP/Interaction/dc8ef http://rdf.wikipathways.org/Pathway/WP1114_r120486/WP/Interaction/ded11 http://rdf.wikipathways.org/Pathway/WP1114_r120486/WP/Interaction/e0356 http://rdf.wikipathways.org/Pathway/WP1114_r120486/WP/Interaction/e7d69 http://rdf.wikipathways.org/Pathway/WP1114_r120486/WP/Interaction/ef554 http://rdf.wikipathways.org/Pathway/WP1114_r120486/WP/Interaction/f0742 http://rdf.wikipathways.org/Pathway/WP1114_r120486/WP/Interaction/f0e5e http://rdf.wikipathways.org/Pathway/WP1114_r120486/WP/Interaction/f9069 http://rdf.wikipathways.org/Pathway/WP1114_r120486/WP/Interaction/f9150 http://rdf.wikipathways.org/Pathway/WP1114_r120486/WP/Interaction/fd421 http://rdf.wikipathways.org/Pathway/WP1114_r120486/WP/Interaction/ff322 http://rdf.wikipathways.org/Pathway/WP1114_r120486/WP/Interaction/id60c0d005 http://rdf.wikipathways.org/Pathway/WP1114_r120486/WP/Interaction/id61d4ba12 http://rdf.wikipathways.org/Pathway/WP1114_r120486/WP/Interaction/ide117a115 https://identifiers.org/wikipathways/WP1114_r120486
http://www.w3.org/1999/02/22-rdf-syntax-ns#type
http://vocabularies.wikipathways.org/wp#Pathway
http://www.w3.org/2004/02/skos/core#Collection
http://vocabularies.wikipathways.org/wp#isAbout
http://rdf.wikipathways.org/Pathway/WP1114_r120486
http://vocabularies.wikipathways.org/wp#ontologyTag
http://vocabularies.wikipathways.org/wp#Curation:Homology_Converted
http://vocabularies.wikipathways.org/wp#Curation:AnalysisCollection
http://purl.obolibrary.org/obo/PW_0000007
http://vocabularies.wikipathways.org/wp#organism
http://purl.obolibrary.org/obo/NCBITaxon_9615
http://vocabularies.wikipathways.org/wp#organismName http://vocabularies.wikipathways.org/wp#pathwayOntologyTag
http://purl.obolibrary.org/obo/PW_0000007
http://xmlns.com/foaf/0.1/img
https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP1114&oldid=120486
https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP1114&oldid=120486
http://xmlns.com/foaf/0.1/page
http://www.wikipathways.org/instance/WP1114_r120486
http://purl.org/dc/elements/1.1/identifier
https://identifiers.org/wikipathways/WP1114
http://purl.org/dc/elements/1.1/source http://purl.org/dc/elements/1.1/title http://purl.org/dc/terms/description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Source: KEGG http://www.genome.jp/dbget-bin/www_bget?pathway:map04010
http://purl.org/dc/terms/identifier http://purl.org/dc/terms/references
https://identifiers.org/pubmed/11749383
https://identifiers.org/pubmed/11369511
https://identifiers.org/pubmed/12566928
https://identifiers.org/pubmed/12191611
https://identifiers.org/pubmed/12390245
https://identifiers.org/pubmed/14597384
https://identifiers.org/pubmed/12947395
https://identifiers.org/pubmed/12676795
https://identifiers.org/pubmed/12849693
http://purl.org/spar/cito/cites
https://identifiers.org/pubmed/17726008
https://identifiers.org/pubmed/11369511
https://identifiers.org/pubmed/11749383
https://identifiers.org/pubmed/12676795
https://identifiers.org/pubmed/12849693
https://identifiers.org/pubmed/12947395
https://identifiers.org/pubmed/14597384
https://identifiers.org/pubmed/12191611
https://identifiers.org/pubmed/12390245
https://identifiers.org/pubmed/12566928
https://identifiers.org/pubmed/22539006
https://identifiers.org/chebi/CHEBI:16412 https://identifiers.org/chebi/CHEBI:16595 https://identifiers.org/chebi/CHEBI:18035 https://identifiers.org/ensembl/ENSCAFG00000000011 https://identifiers.org/ensembl/ENSCAFG00000000251 https://identifiers.org/ensembl/ENSCAFG00000000373 https://identifiers.org/ensembl/ENSCAFG00000000395 https://identifiers.org/ensembl/ENSCAFG00000000484 https://identifiers.org/ensembl/ENSCAFG00000000517 https://identifiers.org/ensembl/ENSCAFG00000000568 https://identifiers.org/ensembl/ENSCAFG00000000639 https://identifiers.org/ensembl/ENSCAFG00000000685 https://identifiers.org/ensembl/ENSCAFG00000000760 https://identifiers.org/ensembl/ENSCAFG00000000981 https://identifiers.org/ensembl/ENSCAFG00000001086 https://identifiers.org/ensembl/ENSCAFG00000001314 https://identifiers.org/ensembl/ENSCAFG00000001324 https://identifiers.org/ensembl/ENSCAFG00000001332 https://identifiers.org/ensembl/ENSCAFG00000001356 https://identifiers.org/ensembl/ENSCAFG00000001378 https://identifiers.org/ensembl/ENSCAFG00000001380 https://identifiers.org/ensembl/ENSCAFG00000001382 https://identifiers.org/ensembl/ENSCAFG00000001508 https://identifiers.org/ensembl/ENSCAFG00000001585 https://identifiers.org/ensembl/ENSCAFG00000001829 https://identifiers.org/ensembl/ENSCAFG00000001886 https://identifiers.org/ensembl/ENSCAFG00000002147 https://identifiers.org/ensembl/ENSCAFG00000002152 https://identifiers.org/ensembl/ENSCAFG00000002162 https://identifiers.org/ensembl/ENSCAFG00000002528 https://identifiers.org/ensembl/ENSCAFG00000002535 https://identifiers.org/ensembl/ENSCAFG00000002704 https://identifiers.org/ensembl/ENSCAFG00000002705 https://identifiers.org/ensembl/ENSCAFG00000002713 https://identifiers.org/ensembl/ENSCAFG00000003123 https://identifiers.org/ensembl/ENSCAFG00000003465 https://identifiers.org/ensembl/ENSCAFG00000003604 https://identifiers.org/ensembl/ENSCAFG00000003838 https://identifiers.org/ensembl/ENSCAFG00000003904 https://identifiers.org/ensembl/ENSCAFG00000003907 https://identifiers.org/ensembl/ENSCAFG00000003980 https://identifiers.org/ensembl/ENSCAFG00000003996 https://identifiers.org/ensembl/ENSCAFG00000004205 https://identifiers.org/ensembl/ENSCAFG00000004313 https://identifiers.org/ensembl/ENSCAFG00000004474 https://identifiers.org/ensembl/ENSCAFG00000004528 https://identifiers.org/ensembl/ENSCAFG00000004597 https://identifiers.org/ensembl/ENSCAFG00000004951 https://identifiers.org/ensembl/ENSCAFG00000004956 https://identifiers.org/ensembl/ENSCAFG00000005014 https://identifiers.org/ensembl/ENSCAFG00000005388 https://identifiers.org/ensembl/ENSCAFG00000005415 https://identifiers.org/ensembl/ENSCAFG00000005449 https://identifiers.org/ensembl/ENSCAFG00000005526 https://identifiers.org/ensembl/ENSCAFG00000005773 https://identifiers.org/ensembl/ENSCAFG00000005870 https://identifiers.org/ensembl/ENSCAFG00000005874 https://identifiers.org/ensembl/ENSCAFG00000005909 https://identifiers.org/ensembl/ENSCAFG00000005926 https://identifiers.org/ensembl/ENSCAFG00000005970 https://identifiers.org/ensembl/ENSCAFG00000006100 https://identifiers.org/ensembl/ENSCAFG00000006175 https://identifiers.org/ensembl/ENSCAFG00000006339 https://identifiers.org/ensembl/ENSCAFG00000006340 https://identifiers.org/ensembl/ENSCAFG00000006426 https://identifiers.org/ensembl/ENSCAFG00000006551 https://identifiers.org/ensembl/ENSCAFG00000006813 https://identifiers.org/ensembl/ENSCAFG00000006845 https://identifiers.org/ensembl/ENSCAFG00000006917 https://identifiers.org/ensembl/ENSCAFG00000006918 https://identifiers.org/ensembl/ENSCAFG00000007046 https://identifiers.org/ensembl/ENSCAFG00000007245 https://identifiers.org/ensembl/ENSCAFG00000007249 https://identifiers.org/ensembl/ENSCAFG00000007338 https://identifiers.org/ensembl/ENSCAFG00000007541 https://identifiers.org/ensembl/ENSCAFG00000007603 https://identifiers.org/ensembl/ENSCAFG00000007674 https://identifiers.org/ensembl/ENSCAFG00000007750 https://identifiers.org/ensembl/ENSCAFG00000008211 https://identifiers.org/ensembl/ENSCAFG00000008302 https://identifiers.org/ensembl/ENSCAFG00000008396 https://identifiers.org/ensembl/ENSCAFG00000008410 https://identifiers.org/ensembl/ENSCAFG00000008525 https://identifiers.org/ensembl/ENSCAFG00000008674 https://identifiers.org/ensembl/ENSCAFG00000008689 https://identifiers.org/ensembl/ENSCAFG00000008719 https://identifiers.org/ensembl/ENSCAFG00000008744 https://identifiers.org/ensembl/ENSCAFG00000008745 https://identifiers.org/ensembl/ENSCAFG00000008857 https://identifiers.org/ensembl/ENSCAFG00000008886 https://identifiers.org/ensembl/ENSCAFG00000009363 https://identifiers.org/ensembl/ENSCAFG00000009390 https://identifiers.org/ensembl/ENSCAFG00000009391 https://identifiers.org/ensembl/ENSCAFG00000009396 https://identifiers.org/ensembl/ENSCAFG00000009532 https://identifiers.org/ensembl/ENSCAFG00000009588 https://identifiers.org/ensembl/ENSCAFG00000009615 https://identifiers.org/ensembl/ENSCAFG00000009735 https://identifiers.org/ensembl/ENSCAFG00000009739 https://identifiers.org/ensembl/ENSCAFG00000009749 https://identifiers.org/ensembl/ENSCAFG00000009914 https://identifiers.org/ensembl/ENSCAFG00000009918 https://identifiers.org/ensembl/ENSCAFG00000009924 https://identifiers.org/ensembl/ENSCAFG00000009926 https://identifiers.org/ensembl/ENSCAFG00000010009 https://identifiers.org/ensembl/ENSCAFG00000010144 https://identifiers.org/ensembl/ENSCAFG00000010155 https://identifiers.org/ensembl/ENSCAFG00000010207 https://identifiers.org/ensembl/ENSCAFG00000010281 https://identifiers.org/ensembl/ENSCAFG00000010431 https://identifiers.org/ensembl/ENSCAFG00000010591 https://identifiers.org/ensembl/ENSCAFG00000010644 https://identifiers.org/ensembl/ENSCAFG00000010688 https://identifiers.org/ensembl/ENSCAFG00000010693 https://identifiers.org/ensembl/ENSCAFG00000010730 https://identifiers.org/ensembl/ENSCAFG00000010758 https://identifiers.org/ensembl/ENSCAFG00000010815 https://identifiers.org/ensembl/ENSCAFG00000010884 https://identifiers.org/ensembl/ENSCAFG00000011193 https://identifiers.org/ensembl/ENSCAFG00000011326 https://identifiers.org/ensembl/ENSCAFG00000011372 https://identifiers.org/ensembl/ENSCAFG00000011428 https://identifiers.org/ensembl/ENSCAFG00000011432 https://identifiers.org/ensembl/ENSCAFG00000011532 https://identifiers.org/ensembl/ENSCAFG00000012144 https://identifiers.org/ensembl/ENSCAFG00000012374 https://identifiers.org/ensembl/ENSCAFG00000013004 https://identifiers.org/ensembl/ENSCAFG00000013067 https://identifiers.org/ensembl/ENSCAFG00000013140 https://identifiers.org/ensembl/ENSCAFG00000013171 https://identifiers.org/ensembl/ENSCAFG00000013230 https://identifiers.org/ensembl/ENSCAFG00000013274 https://identifiers.org/ensembl/ENSCAFG00000013332 https://identifiers.org/ensembl/ENSCAFG00000013334 https://identifiers.org/ensembl/ENSCAFG00000013415 https://identifiers.org/ensembl/ENSCAFG00000013544 https://identifiers.org/ensembl/ENSCAFG00000013641 https://identifiers.org/ensembl/ENSCAFG00000013670 https://identifiers.org/ensembl/ENSCAFG00000013686 https://identifiers.org/ensembl/ENSCAFG00000013774 https://identifiers.org/ensembl/ENSCAFG00000013778 https://identifiers.org/ensembl/ENSCAFG00000014053 https://identifiers.org/ensembl/ENSCAFG00000014216 https://identifiers.org/ensembl/ENSCAFG00000014275 https://identifiers.org/ensembl/ENSCAFG00000014309 https://identifiers.org/ensembl/ENSCAFG00000014678 https://identifiers.org/ensembl/ENSCAFG00000014707 https://identifiers.org/ensembl/ENSCAFG00000014818 https://identifiers.org/ensembl/ENSCAFG00000014923 https://identifiers.org/ensembl/ENSCAFG00000014993 https://identifiers.org/ensembl/ENSCAFG00000015178 https://identifiers.org/ensembl/ENSCAFG00000015188 https://identifiers.org/ensembl/ENSCAFG00000015197 https://identifiers.org/ensembl/ENSCAFG00000015278 https://identifiers.org/ensembl/ENSCAFG00000015361 https://identifiers.org/ensembl/ENSCAFG00000015365 https://identifiers.org/ensembl/ENSCAFG00000015421 https://identifiers.org/ensembl/ENSCAFG00000015603 https://identifiers.org/ensembl/ENSCAFG00000015712 https://identifiers.org/ensembl/ENSCAFG00000015716 https://identifiers.org/ensembl/ENSCAFG00000015806 https://identifiers.org/ensembl/ENSCAFG00000015873 https://identifiers.org/ensembl/ENSCAFG00000015905 https://identifiers.org/ensembl/ENSCAFG00000016031 https://identifiers.org/ensembl/ENSCAFG00000016051 https://identifiers.org/ensembl/ENSCAFG00000016212 https://identifiers.org/ensembl/ENSCAFG00000016488 https://identifiers.org/ensembl/ENSCAFG00000016510 https://identifiers.org/ensembl/ENSCAFG00000016518 https://identifiers.org/ensembl/ENSCAFG00000016528 https://identifiers.org/ensembl/ENSCAFG00000016714 https://identifiers.org/ensembl/ENSCAFG00000016897 https://identifiers.org/ensembl/ENSCAFG00000016903 https://identifiers.org/ensembl/ENSCAFG00000017039 https://identifiers.org/ensembl/ENSCAFG00000017040 https://identifiers.org/ensembl/ENSCAFG00000017101 https://identifiers.org/ensembl/ENSCAFG00000017120 https://identifiers.org/ensembl/ENSCAFG00000017298 https://identifiers.org/ensembl/ENSCAFG00000017334 https://identifiers.org/ensembl/ENSCAFG00000017454 https://identifiers.org/ensembl/ENSCAFG00000017543 https://identifiers.org/ensembl/ENSCAFG00000017571 https://identifiers.org/ensembl/ENSCAFG00000017851 https://identifiers.org/ensembl/ENSCAFG00000018202 https://identifiers.org/ensembl/ENSCAFG00000018214 https://identifiers.org/ensembl/ENSCAFG00000018354 https://identifiers.org/ensembl/ENSCAFG00000018530 https://identifiers.org/ensembl/ENSCAFG00000018592 https://identifiers.org/ensembl/ENSCAFG00000018650 https://identifiers.org/ensembl/ENSCAFG00000018897 https://identifiers.org/ensembl/ENSCAFG00000018898 https://identifiers.org/ensembl/ENSCAFG00000018974 https://identifiers.org/ensembl/ENSCAFG00000019138 https://identifiers.org/ensembl/ENSCAFG00000019157 https://identifiers.org/ensembl/ENSCAFG00000019241 https://identifiers.org/ensembl/ENSCAFG00000019380 https://identifiers.org/ensembl/ENSCAFG00000019429 https://identifiers.org/ensembl/ENSCAFG00000019513 https://identifiers.org/ensembl/ENSCAFG00000019521 https://identifiers.org/ensembl/ENSCAFG00000019541 https://identifiers.org/ensembl/ENSCAFG00000019596 https://identifiers.org/ensembl/ENSCAFG00000019605 https://identifiers.org/ensembl/ENSCAFG00000019707 https://identifiers.org/ensembl/ENSCAFG00000020319 https://identifiers.org/ensembl/ENSCAFG00000020324 https://identifiers.org/ensembl/ENSCAFG00000023317 https://identifiers.org/ensembl/ENSCAFG00000023338 https://identifiers.org/ensembl/ENSCAFG00000023742 https://identifiers.org/ensembl/ENSCAFG00000024815 https://identifiers.org/ensembl/ENSCAFG00000024908 https://identifiers.org/ensembl/ENSCAFG00000028562 https://identifiers.org/ensembl/ENSCAFG00000028570 https://identifiers.org/ensembl/ENSCAFG00000028654 https://identifiers.org/ensembl/ENSCAFG00000029141 https://identifiers.org/ensembl/ENSCAFG00000029191 https://identifiers.org/ensembl/ENSCAFG00000029474 https://identifiers.org/ensembl/ENSCAFG00000029596 https://identifiers.org/ensembl/ENSCAFG00000029809 https://identifiers.org/ensembl/ENSCAFG00000029826 https://identifiers.org/ensembl/ENSCAFG00000029890 https://identifiers.org/ensembl/ENSCAFG00000029975 https://identifiers.org/ensembl/ENSCAFG00000029983 https://identifiers.org/ensembl/ENSCAFG00000030112 https://identifiers.org/ensembl/ENSCAFG00000030240 https://identifiers.org/ensembl/ENSCAFG00000030297 https://identifiers.org/ensembl/ENSCAFG00000031029 https://identifiers.org/ensembl/ENSCAFG00000031187 https://identifiers.org/ensembl/ENSCAFG00000031522 https://identifiers.org/ensembl/ENSCAFG00000031724 https://identifiers.org/ensembl/ENSCAFG00000031793 https://identifiers.org/ensembl/ENSCAFG00000031965 https://identifiers.org/ensembl/ENSCAFG00000032027 https://identifiers.org/ensembl/ENSCAFG00000032667 https://identifiers.org/ensembl/ENSCAFG00000032672 https://identifiers.org/ensembl/ENSCAFG00000032695 https://identifiers.org/hmdb/HMDB0000058 https://identifiers.org/hmdb/HMDB0000464 https://identifiers.org/pubmed/11369511 https://identifiers.org/pubmed/11749383 https://identifiers.org/pubmed/12191611 https://identifiers.org/pubmed/12390245 https://identifiers.org/pubmed/12566928 https://identifiers.org/pubmed/12676795 https://identifiers.org/pubmed/12849693 https://identifiers.org/pubmed/12947395 https://identifiers.org/pubmed/14597384 https://identifiers.org/wikipathways/WP1114 https://identifiers.org/wikipathways/WP1129 https://identifiers.org/wikipathways/WP1137 https://identifiers.org/wikipathways/WP1200