SPARQL | HTML5 RDFa and Microdata document
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    • http://purl.org/dc/terms/isPartOf
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    • http://purl.org/dc/terms/isPartOf
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    • http://purl.org/dc/terms/isPartOf
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    • http://purl.org/dc/terms/isPartOf
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    • http://purl.org/dc/terms/isPartOf
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    • http://purl.org/dc/terms/isPartOf
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    • http://purl.org/dc/terms/isPartOf
      • https://identifiers.org/wikipathways/WP1241_r106835
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    • http://purl.org/dc/terms/isPartOf
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    • http://purl.org/dc/terms/isPartOf
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    • http://purl.org/dc/terms/isPartOf
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    • http://purl.org/dc/terms/isPartOf
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    • http://purl.org/dc/terms/isPartOf
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    • http://purl.org/dc/terms/isPartOf
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  • https://identifiers.org/wikipathways/WP1241_r106835
    • http://www.w3.org/1999/02/22-rdf-syntax-ns#type
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      • http://www.w3.org/2004/02/skos/core#Collection
    • http://vocabularies.wikipathways.org/wp#isAbout
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      • http://purl.obolibrary.org/obo/NCBITaxon_10090
    • http://vocabularies.wikipathways.org/wp#organismName
      • Mus musculus
    • http://vocabularies.wikipathways.org/wp#pathwayOntologyTag
      • http://purl.obolibrary.org/obo/PW_0000859
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      • WikiPathways
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      • Glucuronidation
    • http://purl.org/dc/terms/description
      • Metabolism of xenobiotic compounds consists of phase I and a phase II biotransformation reactions, being compound modification and conjugation reactions respectively. In phase I biotransformation, the compound is modificated via oxidation, reduction, hydrolysis, or other minor reactions, to reveal a reactive group to which a conjugation molecule can react to. In phase II, a small conjugation molecule reacts with the phase I modified molecule, producing a much more water-soluble molecule that can be excreted more easily. Glucuronidation is a phase II biotransformation reaction in which glucuronide acts as a conjugation molecule and binds to a substrate via the catalysis of glucuronosyltransferases. First, in a series of reactions the cosubstrate uridine diphosphate glucuronic acid (UDPGA) is formed. The glucuronosyltransferases (UGTs) then catalyze the transfer of glucuronic acid from UDPGA to a substrate resulting in a glucuronidated substrate and leaving uridine 5'-diphosphate. UGTs are a very broad and divers group of enzymes and count as the most significant group of conjugation enzymes in xenobiotic metabolism, qualitatively because glucuronic acid can be coupled to a large diversity of functional groups and quantitatively because of the large and divers number of substrates that are formed.
    • http://purl.org/dc/terms/identifier
      • WP1241
    • http://purl.org/dc/terms/references
      • https://identifiers.org/pubmed/19035562
    • http://purl.org/spar/cito/cites
      • https://identifiers.org/pubmed/19244115
      • https://identifiers.org/pubmed/19035562