SPARQL | HTML5 RDFa and Microdata document
https://identifiers.org/chebi/CHEBI:13956
https://identifiers.org/chebi/CHEBI:36498
https://identifiers.org/ensembl/ENSG00000198964
https://identifiers.org/hmdb/HMDB0000140
https://identifiers.org/hmdb/HMDB0000252
https://identifiers.org/hmdb/HMDB0001383
https://identifiers.org/hmdb/HMDB0006752
https://identifiers.org/ncbigene/204219
https://identifiers.org/ncbigene/64781
https://identifiers.org/uniprot/Q86VZ5
https://identifiers.org/wikidata/Q17117943
https://identifiers.org/wikidata/Q21105760
https://identifiers.org/wikidata/Q21115762
https://identifiers.org/hmdb/HMDB0000024
https://identifiers.org/hmdb/HMDB0001348
https://identifiers.org/pubmed/17928229
https://identifiers.org/pubmed/19029065
https://identifiers.org/ec-code/3.2.1.45
https://identifiers.org/ec-code/4.1.2.27
https://identifiers.org/ensembl/ENSG00000113163
https://identifiers.org/ensembl/ENSG00000167769
https://identifiers.org/lipidmaps/LMSP0501AB14
https://identifiers.org/ncbigene/55304
https://identifiers.org/ncbigene/56624
https://identifiers.org/ncbigene/57515
https://identifiers.org/wikidata/Q27088847
https://identifiers.org/wikidata/Q27109281
https://identifiers.org/wikidata/Q37611218
https://identifiers.org/wikidata/Q420762
https://identifiers.org/ensembl/ENSG00000174607
https://identifiers.org/hmdb/HMDB0004949
https://identifiers.org/ncbigene/130367
https://identifiers.org/ncbigene/56848
https://identifiers.org/ncbigene/57704
https://identifiers.org/ncbigene/8611
https://identifiers.org/ncbigene/9331
https://identifiers.org/ncbigene/9517
https://identifiers.org/ec-code/3.5.1.23
https://identifiers.org/wikipathways/WP1422
https://identifiers.org/chebi/CHEBI:17862
https://identifiers.org/ensembl/ENSG00000119537
https://identifiers.org/hmdb/HMDB0000187
https://identifiers.org/hmdb/HMDB0000269
https://identifiers.org/hmdb/HMDB0000277
https://identifiers.org/hmdb/HMDB0001338
https://identifiers.org/hmdb/HMDB0006750
https://identifiers.org/ncbigene/10558
https://identifiers.org/ncbigene/2531
https://identifiers.org/ncbigene/2629
https://identifiers.org/ncbigene/29956
https://identifiers.org/ncbigene/427
https://identifiers.org/ncbigene/5499
https://identifiers.org/ncbigene/79603
https://identifiers.org/ncbigene/8877
https://identifiers.org/uniprot/Q16739
https://identifiers.org/uniprot/Q8NHU3
https://identifiers.org/ncbigene/5515
https://identifiers.org/ncbigene/9514
https://identifiers.org/chebi/CHEBI:17553
https://identifiers.org/ensembl/ENSG00000166224
https://identifiers.org/lipidmaps/LMSP030100A0
https://identifiers.org/ec-code/3.1.3.16
https://identifiers.org/lipidmaps/LMSP0501AA04
https://identifiers.org/ncbigene/253782
https://identifiers.org/ncbigene/91012
http://rdf.wikipathways.org/Pathway/WP1422_r118359/WP/Interaction/a17ed
http://rdf.wikipathways.org/Pathway/WP1422_r118359/WP/Interaction/a18ae
http://rdf.wikipathways.org/Pathway/WP1422_r118359/WP/Interaction/a4bef
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http://rdf.wikipathways.org/Pathway/WP1422_r118359/WP/Interaction/b26d9
http://rdf.wikipathways.org/Pathway/WP1422_r118359/WP/Interaction/b4350
http://rdf.wikipathways.org/Pathway/WP1422_r118359/WP/Interaction/b6684
http://rdf.wikipathways.org/Pathway/WP1422_r118359/WP/Interaction/bd3ce
http://rdf.wikipathways.org/Pathway/WP1422_r118359/WP/Interaction/bd43a
http://rdf.wikipathways.org/Pathway/WP1422_r118359/WP/Interaction/bf461
http://rdf.wikipathways.org/Pathway/WP1422_r118359/WP/Interaction/ca982
http://rdf.wikipathways.org/Pathway/WP1422_r118359/WP/Interaction/cc8b0
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http://rdf.wikipathways.org/Pathway/WP1422_r118359/WP/Interaction/f5cd8
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http://rdf.wikipathways.org/Pathway/WP1422_r118359/WP/Interaction/id12d8a1bc
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http://rdf.wikipathways.org/Pathway/WP1422_r118359/WP/Interaction/id239bcc18
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http://rdf.wikipathways.org/Pathway/WP1422_r118359/WP/Interaction/idedd601a1
http://rdf.wikipathways.org/Pathway/WP1422_r118359/WP/Interaction/idede2a097
https://identifiers.org/wikipathways/WP1422_r118359
http://www.w3.org/1999/02/22-rdf-syntax-ns#type
http://www.w3.org/2004/02/skos/core#Collection
http://vocabularies.wikipathways.org/wp#Pathway
http://vocabularies.wikipathways.org/wp#isAbout
http://rdf.wikipathways.org/Pathway/WP1422_r118359
http://vocabularies.wikipathways.org/wp#ontologyTag
http://purl.obolibrary.org/obo/PW_0000197
http://vocabularies.wikipathways.org/wp#Curation:AnalysisCollection
http://vocabularies.wikipathways.org/wp#Curation:ONTOX
http://vocabularies.wikipathways.org/wp#organism
http://purl.obolibrary.org/obo/NCBITaxon_9606
http://vocabularies.wikipathways.org/wp#organismName
http://vocabularies.wikipathways.org/wp#pathwayOntologyTag
http://purl.obolibrary.org/obo/PW_0000197
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http://www.wikipathways.org/instance/WP1422_r118359
http://purl.org/dc/elements/1.1/identifier
https://identifiers.org/wikipathways/WP1422
http://purl.org/dc/elements/1.1/source
http://purl.org/dc/elements/1.1/title
http://purl.org/dc/terms/description
The sphingolipid metabolites and genes (with the gene abbreviations shown in boxes, or enzyme names where gene names are ambiguous) are given for the condensation of serine and palmitoyl-CoA to form 3-ketosphinganine (3-ketoSa) by serine palmitoyltransferase, which is reduced to sphinganine (Sa), acylated to dihydroceramides, DHCer, by (DH)Cer synthases, and incorporated into more complex DH-sphingolipids (the 1-phosphate, DHCerP, sphingomyelins, DHSM, glucosylceramides, DHGlcCer, galactosylceramides, DHGalCer, lactosylceramides, DHLacCer, and sulfatides, or desaturated to Cer followed by headgroup addition. Also included are a number of the catabolic genes, e.g., sphingomyelinases, SMases, ceramidases, ASAH, sphingosine kinases, for the formation of sphinganine 1-phosphate (Sa1P) and sphingosine 1-phosphate (So1P), and phosphatases for the reverse reaction and the lyase that cleaves sphingoid base 1-phosphates to ethanolamine phosphate (EP), hexadecanal (C16:0al) and hexadecenal (C16:1al).
This pathway has been updated with information from Lipidmaps>Sphingolipids [https://lipidmaps.org/resources/pathways/vanted.php]. Metabolites and proteins from this pathway are coloured orange and have a rounded rectangle shape (where an oval shape indicates that the node only occures in the LipidMaps pathway). Reactions occurring in the lipidmaps pathways are coloured orange (where a dashed line indicates that the reaction only occures in the LipidMaps pathway).
http://purl.org/dc/terms/identifier
http://purl.org/dc/terms/references
https://identifiers.org/pubmed/17928229
https://identifiers.org/pubmed/19029065
http://purl.org/spar/cito/cites
https://identifiers.org/pubmed/19029065
https://identifiers.org/pubmed/17928229
https://identifiers.org/pubmed/18216770