SPARQL | HTML5 RDFa and Microdata document
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      • Homo sapiens
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      • Sphingolipid pathway
    • http://purl.org/dc/terms/description
      • The sphingolipid metabolites and genes (with the gene abbreviations shown in boxes, or enzyme names where gene names are ambiguous) are given for the condensation of serine and palmitoyl-CoA to form 3-ketosphinganine (3-ketoSa) by serine palmitoyltransferase, which is reduced to sphinganine (Sa), acylated to dihydroceramides, DHCer, by (DH)Cer synthases, and incorporated into more complex DH-sphingolipids (the 1-phosphate, DHCerP, sphingomyelins, DHSM, glucosylceramides, DHGlcCer, galactosylceramides, DHGalCer, lactosylceramides, DHLacCer, and sulfatides, or desaturated to Cer followed by headgroup addition. Also included are a number of the catabolic genes, e.g., sphingomyelinases, SMases, ceramidases, ASAH, sphingosine kinases, for the formation of sphinganine 1-phosphate (Sa1P) and sphingosine 1-phosphate (So1P), and phosphatases for the reverse reaction and the lyase that cleaves sphingoid base 1-phosphates to ethanolamine phosphate (EP), hexadecanal (C16:0al) and hexadecenal (C16:1al). This pathway has been updated with information from [Lipidmaps>Sphingolipids](https://lipidmaps.org/resources/pathways/vanted.php). Metabolites and proteins from this pathway are coloured orange and have a rounded rectangle shape (where an oval shape indicates that the node only occurs in the LipidMaps pathway). Reactions occurring in the lipidmaps pathways are coloured orange (where a dashed line indicates that the reaction only occurs in the LipidMaps pathway).
    • http://purl.org/dc/terms/identifier
      • WP1422
    • http://purl.org/dc/terms/references
      • https://identifiers.org/pubmed/17928229
      • https://identifiers.org/pubmed/19029065
    • http://purl.org/spar/cito/cites
      • https://identifiers.org/pubmed/18216770
      • https://identifiers.org/pubmed/19029065
      • https://identifiers.org/pubmed/17928229