SPARQL | HTML5 RDFa and Microdata document
  • https://identifiers.org/wikipathways/WP1991
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  • https://identifiers.org/wikipathways/WP1991_r117830
    • http://www.w3.org/1999/02/22-rdf-syntax-ns#type
      • http://vocabularies.wikipathways.org/wp#Pathway
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      • http://www.wikipathways.org/instance/WP1991_r117830
    • http://purl.org/dc/elements/1.1/identifier
      • https://identifiers.org/wikipathways/WP1991
    • http://purl.org/dc/elements/1.1/source
      • WikiPathways
    • http://purl.org/dc/elements/1.1/title
      • SRF and miRs in smooth muscle differentiation and proliferation
    • http://purl.org/dc/terms/description
      • Smooth muscle cells exhibit a unique plasticity, in that they are able to oscillate between proliferative and more quiescent, differentiated states. These two states are determined, in part, by a network of transcription factors, including Klf-4, Elk-1 and serum response factor (SRF), that regulate expression of genes controlling smooth muscle cell status. Two smooth muscle-enriched, co-transcribed microRNAs (miRNAs), miR-143 and miR-145, cooperatively target this transcription factor network to promote smooth muscle cell differentiation. miR-145 also acts in a positive feed-foward regulatory loop to enhance expression of the smooth muscle regulator, Myocardin (Myocd), which cooperates with SRF to activate transcription of miR-143/145. Conversely, the cardiac and skeletal muscle-enriched miRNA, miR-133, which is also under transcriptional control of both SRF and Mef2C, acts in a negative feed-back loop to decrease SRF translation. Other miRNAs, including miR-214 and miR-199a, also target SRF, limiting its activity in specific cell types.
    • http://purl.org/dc/terms/identifier
      • WP1991
    • http://purl.org/spar/cito/cites
      • https://identifiers.org/pubmed/19578358
      • https://identifiers.org/pubmed/21473868
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      • http://purl.obolibrary.org/obo/CL_0000027
      • http://purl.obolibrary.org/obo/CL_0000514
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      • http://purl.obolibrary.org/obo/CL_0000514
      • http://purl.obolibrary.org/obo/CL_0000027
      • http://vocabularies.wikipathways.org/wp#Curation:AnalysisCollection
      • http://vocabularies.wikipathways.org/wp#Curation:ExRNA
      • http://purl.obolibrary.org/obo/PW_0000808
    • http://vocabularies.wikipathways.org/wp#organism
      • http://purl.obolibrary.org/obo/NCBITaxon_9606
    • http://vocabularies.wikipathways.org/wp#organismName
      • Homo sapiens
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      • http://purl.obolibrary.org/obo/PW_0000808
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