Human thyroid-stimulating hormone (TSH) is a glycoprotein hormone secreted from the anterior pituitary lobe, which plays an important physiological role in the regulation of the hypothalamus-pituitary-thyroid axis by stimulating production and secretion of the thyroid hormone from the thyroid gland and – on a longer time scale – growth and differentiation of thyrocytes. TSH binds to TSH receptor which is a member of the G protein-coupled receptor superfamily of integral membrane proteins. TSH exerts its action through various signaling cascades such as cAMP cascade and the phospholipase C beta-mediated inositol phosphate generation. Further, it will give signaling to NF-kappa B, mitogen activated protein kinases, protein kinase C modules.
[NetPath](http://www.netpath.org) is a collaborative project between [PandeyLab at Johns Hopkins University](http://pandeylab.igm.jhmi.edu) and the [Institute of Bioinformatics](http://www.ibioinformatics.org). If you use this pathway, please cite the NetPath website until the pathway is published.
Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP2032).