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This pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that involves the regulation of gene expression and signaling in motor neurons, oligodentrocytes, microglia, and astrocytes that trigger immediate immune responses lasting several weeks. Within 24 hours, chemoattractants and cytokines released from the site of injury activate neutrophils which further recruit B and T cells or recruit monocytes that ultimately result in infiltration and activation by microglia and macrophages. These immune responses result in inflammation, excitotoxicity, cell death, formation of glial scar, and suppression of axonal regeneration. An increase in the expression of cell cycle genes further results in proliferation of astrocytes and microglia that leads to apoptosis and necrosis of oligodentrocytes and neurons. An example therapy is the administration of the immunosuppressant FK506, also used in transplantation to offer neuroprotection.
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2431 CPTAC Assay Portal].
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https://identifiers.org/pubmed/22564823
https://identifiers.org/pubmed/22771695
https://identifiers.org/pubmed/18637713
https://identifiers.org/pubmed/19350383
https://identifiers.org/pubmed/19932745
https://identifiers.org/pubmed/20304963
https://identifiers.org/pubmed/21092735
https://identifiers.org/pubmed/21168495
https://identifiers.org/pubmed/9872457
https://identifiers.org/pubmed/16602711
https://identifiers.org/pubmed/17482149
https://identifiers.org/pubmed/17567803
https://identifiers.org/pubmed/17621255
https://identifiers.org/pubmed/17629414
https://identifiers.org/pubmed/17698296
https://identifiers.org/pubmed/17706365
https://identifiers.org/pubmed/17917587
https://identifiers.org/pubmed/18267965
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