SPARQL | HTML5 RDFa and Microdata document
https://identifiers.org/hmdb/HMDB0001043
https://identifiers.org/hmdb/HMDB0001381
https://identifiers.org/pubmed/21673720
https://identifiers.org/cas/104987-11-3
https://identifiers.org/hmdb/HMDB0035233
https://identifiers.org/pubchem.compound/145068
https://identifiers.org/pubchem.compound/16133648
https://identifiers.org/pubchem.compound/169
https://identifiers.org/ncbigene/469616
https://identifiers.org/ensembl/ENSRNOG00000000632
https://identifiers.org/ensembl/ENSRNOG00000000837
https://identifiers.org/ensembl/ENSRNOG00000001849
https://identifiers.org/ensembl/ENSRNOG00000002792
https://identifiers.org/ensembl/ENSRNOG00000003256
https://identifiers.org/ensembl/ENSRNOG00000003491
https://identifiers.org/ensembl/ENSRNOG00000004496
https://identifiers.org/ensembl/ENSRNOG00000004500
https://identifiers.org/ensembl/ENSRNOG00000004649
https://identifiers.org/ensembl/ENSRNOG00000005392
https://identifiers.org/ensembl/ENSRNOG00000005615
https://identifiers.org/ensembl/ENSRNOG00000005853
https://identifiers.org/ensembl/ENSRNOG00000007468
https://identifiers.org/ensembl/ENSRNOG00000007624
https://identifiers.org/ensembl/ENSRNOG00000008015
https://identifiers.org/ensembl/ENSRNOG00000009882
https://identifiers.org/ensembl/ENSRNOG00000010278
https://identifiers.org/ensembl/ENSRNOG00000010475
https://identifiers.org/ensembl/ENSRNOG00000010756
https://identifiers.org/ensembl/ENSRNOG00000013925
https://identifiers.org/ensembl/ENSRNOG00000016029
https://identifiers.org/ensembl/ENSRNOG00000016281
https://identifiers.org/ensembl/ENSRNOG00000016708
https://identifiers.org/ensembl/ENSRNOG00000017469
https://identifiers.org/ensembl/ENSRNOG00000017539
https://identifiers.org/ensembl/ENSRNOG00000018580
https://identifiers.org/ensembl/ENSRNOG00000019422
https://identifiers.org/ensembl/ENSRNOG00000020652
https://identifiers.org/ensembl/ENSRNOG00000020918
https://identifiers.org/ensembl/ENSRNOG00000050519
https://identifiers.org/ensembl/ENSRNOG00000057443
https://identifiers.org/ncbigene/140586
https://identifiers.org/ncbigene/24225
https://identifiers.org/ensembl/ENSRNOG00000053583
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This pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multi-step process that involves the regulation of gene expression and signaling in motor neurons, oligodentrocytes, microglia, and astrocytes that trigger immediate immune responses lasting several weeks. Within 24 hours, chemoattractants and cytokines released from the site of injury activate neutrophils which further recruit B and T cells or recruit monocytes that ultimately result in infiltration and activation by microglia and macrophages. These immune responses result in inflammation, excitotoxicity, cell death, formation of glial scar, and suppression of axonal regeneration. An increase in the expression of cell cycle genes further results in proliferation of astrocytes and microglia that leads to apoptosis and necrosis of oligodentrocytes and neurons.
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