SPARQL | HTML5 RDFa and Microdata document
http://rdf.wikipathways.org/Pathway/WP2526_r123068/Complex/a2628 http://rdf.wikipathways.org/Pathway/WP2526_r123068/Complex/ec31a http://rdf.wikipathways.org/Pathway/WP2526_r123068/Complex/fb8d4 http://rdf.wikipathways.org/Pathway/WP2526_r123068/ComplexBinding/a2628 http://rdf.wikipathways.org/Pathway/WP2526_r123068/ComplexBinding/ec31a http://rdf.wikipathways.org/Pathway/WP2526_r123068/ComplexBinding/fb8d4 http://rdf.wikipathways.org/Pathway/WP2526_r123068/WP/Interaction/a5c13 http://rdf.wikipathways.org/Pathway/WP2526_r123068/WP/Interaction/a5e72 http://rdf.wikipathways.org/Pathway/WP2526_r123068/WP/Interaction/acf9d http://rdf.wikipathways.org/Pathway/WP2526_r123068/WP/Interaction/b5d02 http://rdf.wikipathways.org/Pathway/WP2526_r123068/WP/Interaction/b6b78 http://rdf.wikipathways.org/Pathway/WP2526_r123068/WP/Interaction/b7ba5 http://rdf.wikipathways.org/Pathway/WP2526_r123068/WP/Interaction/c1424 http://rdf.wikipathways.org/Pathway/WP2526_r123068/WP/Interaction/c9641 http://rdf.wikipathways.org/Pathway/WP2526_r123068/WP/Interaction/cc256 http://rdf.wikipathways.org/Pathway/WP2526_r123068/WP/Interaction/cc58d http://rdf.wikipathways.org/Pathway/WP2526_r123068/WP/Interaction/ce440 http://rdf.wikipathways.org/Pathway/WP2526_r123068/WP/Interaction/ce697 http://rdf.wikipathways.org/Pathway/WP2526_r123068/WP/Interaction/d2cea http://rdf.wikipathways.org/Pathway/WP2526_r123068/WP/Interaction/d7f2a http://rdf.wikipathways.org/Pathway/WP2526_r123068/WP/Interaction/d84e3 http://rdf.wikipathways.org/Pathway/WP2526_r123068/WP/Interaction/dc112 http://rdf.wikipathways.org/Pathway/WP2526_r123068/WP/Interaction/ddfe1 http://rdf.wikipathways.org/Pathway/WP2526_r123068/WP/Interaction/e40d1 http://rdf.wikipathways.org/Pathway/WP2526_r123068/WP/Interaction/eb933 http://rdf.wikipathways.org/Pathway/WP2526_r123068/WP/Interaction/f3002 http://rdf.wikipathways.org/Pathway/WP2526_r123068/WP/Interaction/f4556 http://rdf.wikipathways.org/Pathway/WP2526_r123068/WP/Interaction/id2624d99f http://rdf.wikipathways.org/Pathway/WP2526_r123068/WP/Interaction/id5e3d61b9 http://rdf.wikipathways.org/Pathway/WP2526_r123068/WP/Interaction/id7141f9b9 http://rdf.wikipathways.org/Pathway/WP2526_r123068/WP/Interaction/id78056d74 http://rdf.wikipathways.org/Pathway/WP2526_r123068/WP/Interaction/id7d2d8850 http://rdf.wikipathways.org/Pathway/WP2526_r123068/WP/Interaction/id89a9901c http://rdf.wikipathways.org/Pathway/WP2526_r123068/WP/Interaction/id958daf74 http://rdf.wikipathways.org/Pathway/WP2526_r123068/WP/Interaction/id96a554a1 http://rdf.wikipathways.org/Pathway/WP2526_r123068/WP/Interaction/idb28e0cda http://rdf.wikipathways.org/Pathway/WP2526_r123068/WP/Interaction/idcdaa57e2 http://rdf.wikipathways.org/Pathway/WP2526_r123068/WP/Interaction/idd3303bc http://rdf.wikipathways.org/Pathway/WP2526_r123068/WP/Interaction/idda5d24a0 https://identifiers.org/ncbigene/5154 https://identifiers.org/ncbigene/5155 https://identifiers.org/uniprot/O00401 https://identifiers.org/uniprot/P40763 https://identifiers.org/uniprot/P60953 https://identifiers.org/uniprot/P61586 https://identifiers.org/uniprot/P63000 https://identifiers.org/ensembl/ENSG00000116711 https://identifiers.org/ensembl/ENSG00000145715 https://identifiers.org/kegg.genes/4790 https://identifiers.org/lipidmaps/LMGL02010000 https://identifiers.org/lipidmaps/LMGP08010003 https://identifiers.org/uniprot/P53365 https://identifiers.org/wikipathways/WP2526 https://identifiers.org/wikipathways/WP2526_r123068
http://www.w3.org/1999/02/22-rdf-syntax-ns#type
http://www.w3.org/2004/02/skos/core#Collection
http://vocabularies.wikipathways.org/wp#Pathway
http://vocabularies.wikipathways.org/wp#diseaseOntologyTag
http://purl.obolibrary.org/obo/DOID_162
http://vocabularies.wikipathways.org/wp#isAbout
http://rdf.wikipathways.org/Pathway/WP2526_r123068
http://vocabularies.wikipathways.org/wp#ontologyTag
http://purl.obolibrary.org/obo/PW_0000209
http://purl.obolibrary.org/obo/PW_0000297
http://vocabularies.wikipathways.org/wp#Curation:AnalysisCollection
http://vocabularies.wikipathways.org/wp#Curation:PancCanNet
http://vocabularies.wikipathways.org/wp#Curation:CPTAC
http://vocabularies.wikipathways.org/wp#Curation:ONTOX
http://purl.obolibrary.org/obo/DOID_162
http://vocabularies.wikipathways.org/wp#organism
http://purl.obolibrary.org/obo/NCBITaxon_9606
http://vocabularies.wikipathways.org/wp#organismName http://vocabularies.wikipathways.org/wp#pathwayOntologyTag
http://purl.obolibrary.org/obo/PW_0000209
http://purl.obolibrary.org/obo/PW_0000297
http://xmlns.com/foaf/0.1/img
https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP2526&oldid=123068
https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP2526&oldid=123068
http://xmlns.com/foaf/0.1/page
http://www.wikipathways.org/instance/WP2526_r123068
http://purl.org/dc/elements/1.1/identifier
https://identifiers.org/wikipathways/WP2526
http://purl.org/dc/elements/1.1/source http://purl.org/dc/elements/1.1/title http://purl.org/dc/terms/description
PDGF belongs to the PDGF/VEGF (vascular endothelial growth factor) family, which is characterized by eight strictly conserved cysteine residues with similar spacing in between (Joukov et al., 1997; Heldin and Westermark, 1999). The A-, B-, C-, and D-chain genes of PDGF are localized to the chromosomes 7p22, 22q13, 4q31, and 11q22, respectively, and their expression is independently regulated. Two forms of the PDGF A-chain, containing 196 and 211 amino acid residues resulting from differential splicing of the transcript, are synthesized, dimerized, proteolytically processed in the Nterminus, and secreted from the cell as a ~30 kDa dimer. The PDGF B chain encoding 241 amino acid residues is dimerized, processed by additional proteolysis, and secreted as a 24 kDa dimer. The homodimers PDGF AA, BB, and the heterodimer AB contain three intrachain disulfide bonds made between the 1st.
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2526 CPTAC Assay Portal]
http://purl.org/dc/terms/identifier http://purl.org/spar/cito/cites
https://identifiers.org/pubmed/1661577
https://identifiers.org/pubmed/1755382
https://identifiers.org/pubmed/2545232
https://identifiers.org/pubmed/21769672
https://identifiers.org/pubmed/22512244
https://identifiers.org/pubmed/2841963
https://identifiers.org/pubmed/20657170
https://identifiers.org/pubmed/2546599
https://identifiers.org/pubmed/2557116
https://identifiers.org/pubmed/18483217
https://identifiers.org/hmdb/HMDB0001335 https://identifiers.org/uniprot/P52735 https://identifiers.org/uniprot/Q13009 https://identifiers.org/uniprot/Q13233 https://identifiers.org/chebi/CHEBI:15378 https://identifiers.org/chebi/CHEBI:16247 https://identifiers.org/chebi/CHEBI:16595 https://identifiers.org/chebi/CHEBI:29101 https://identifiers.org/chebi/CHEBI:29108 https://identifiers.org/ensembl/ENSG00000113721 https://identifiers.org/ensembl/ENSG00000124181 https://identifiers.org/hmdb/HMDB0000058 https://identifiers.org/hmdb/HMDB0001043 https://identifiers.org/ncbigene/3265 https://identifiers.org/ncbigene/4790 https://identifiers.org/ncbigene/5594 https://identifiers.org/ncbigene/5595 https://identifiers.org/ncbigene/6416 https://identifiers.org/uniprot/O15111 https://identifiers.org/uniprot/P00403 https://identifiers.org/uniprot/P01100 https://identifiers.org/uniprot/P04049 https://identifiers.org/uniprot/P05412 https://identifiers.org/uniprot/P11831 https://identifiers.org/uniprot/P12931 https://identifiers.org/uniprot/P15498 https://identifiers.org/uniprot/P19419 https://identifiers.org/uniprot/P23458 https://identifiers.org/uniprot/P25963 https://identifiers.org/uniprot/P27986 https://identifiers.org/uniprot/P29353 https://identifiers.org/uniprot/P42224 https://identifiers.org/uniprot/P45983 https://identifiers.org/uniprot/P62993 https://identifiers.org/uniprot/Q02750 https://identifiers.org/uniprot/Q06124 https://identifiers.org/uniprot/Q07889 https://identifiers.org/uniprot/Q13153 https://identifiers.org/wikipathways/WP306