SPARQL | HTML5 RDFa and Microdata document
http://rdf.wikipathways.org/Pathway/WP2643_r137818/WP/Interaction/id14603671 http://rdf.wikipathways.org/Pathway/WP2643_r137818/WP/Interaction/id1cce1fdf http://rdf.wikipathways.org/Pathway/WP2643_r137818/WP/Interaction/id30035201 http://rdf.wikipathways.org/Pathway/WP2643_r137818/WP/Interaction/id36ad54b6 http://rdf.wikipathways.org/Pathway/WP2643_r137818/WP/Interaction/id41c0b1a4 http://rdf.wikipathways.org/Pathway/WP2643_r137818/WP/Interaction/id5d7283b7 http://rdf.wikipathways.org/Pathway/WP2643_r137818/WP/Interaction/id68650180 http://rdf.wikipathways.org/Pathway/WP2643_r137818/WP/Interaction/id6e27e155 http://rdf.wikipathways.org/Pathway/WP2643_r137818/WP/Interaction/id708ea6ae http://rdf.wikipathways.org/Pathway/WP2643_r137818/WP/Interaction/id850f8b1 http://rdf.wikipathways.org/Pathway/WP2643_r137818/WP/Interaction/id87a8ea12 http://rdf.wikipathways.org/Pathway/WP2643_r137818/WP/Interaction/id92f8344e http://rdf.wikipathways.org/Pathway/WP2643_r137818/WP/Interaction/id99085b14 http://rdf.wikipathways.org/Pathway/WP2643_r137818/WP/Interaction/id9abc7e4d http://rdf.wikipathways.org/Pathway/WP2643_r137818/WP/Interaction/idbbd92d20 http://rdf.wikipathways.org/Pathway/WP2643_r137818/WP/Interaction/idc9a48474 http://rdf.wikipathways.org/Pathway/WP2643_r137818/WP/Interaction/idddf7ef70 http://rdf.wikipathways.org/Pathway/WP2643_r137818/WP/Interaction/ide3e8361 http://rdf.wikipathways.org/Pathway/WP2643_r137818/WP/Interaction/idea62baad http://rdf.wikipathways.org/Pathway/WP2643_r137818/WP/Interaction/idf00a7c3d http://rdf.wikipathways.org/Pathway/WP2643_r137818/WP/Interaction/idf53fa45f http://rdf.wikipathways.org/Pathway/WP2643_r137818/WP/Interaction/idf6001ee4 http://rdf.wikipathways.org/Pathway/WP2643_r137818/WP/Interaction/idf76f30f https://identifiers.org/wikipathways/WP2643_r137818
http://www.w3.org/1999/02/22-rdf-syntax-ns#type
http://www.w3.org/2004/02/skos/core#Collection
http://vocabularies.wikipathways.org/wp#Pathway
http://xmlns.com/foaf/0.1/page
http://www.wikipathways.org/instance/WP2643_r137818
http://purl.org/dc/elements/1.1/identifier
https://identifiers.org/wikipathways/WP2643
http://purl.org/dc/elements/1.1/source http://purl.org/dc/elements/1.1/title
Nanoparticle-mediated activation of receptor signaling
http://purl.org/dc/terms/description
Nanoparticle-mediated activation of receptor signaling. Several NP formulations were shown to interact with cellular receptors such as the EGFR and integrins, inducing cellular phenotypes such as proliferation, apoptosis, differentiation, and migration. In lung epithelial cells, NPs interact with both EGFR and integrins, leading to cell proliferation via activation of PI3K and AKT. NPs were shown to activate the EGFR, leading in parallel to apoptosis and proliferation, and oncogenic Ras mutations might influence these effects. Interestingly, while integrin-mediated activation of ERK was instrumental for proliferation, apoptosis was mediated via activation of JNK. In addition, NPs (PM2.5) are able to bind the EGFR to activate the MAPK signaling cascade. Activation of ERK leads to the expression and secretion of the epidermal growth factor amphiregulin, thus forming an autocrine loop, which might be instrumental for sustained inflammatory responses. Nanoparticles are depicted as red circles.
Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP2643).
http://purl.org/dc/terms/identifier http://purl.org/dc/terms/references
https://identifiers.org/pubmed/23428231
http://purl.org/spar/cito/cites
https://identifiers.org/pubmed/23428231
http://vocabularies.wikipathways.org/wp#isAbout
http://rdf.wikipathways.org/Pathway/WP2643_r137818
http://vocabularies.wikipathways.org/wp#ontologyTag
http://vocabularies.wikipathways.org/wp#Curation:Nanomaterials
http://purl.obolibrary.org/obo/PW_0001435
http://purl.obolibrary.org/obo/PW_0000003
http://vocabularies.wikipathways.org/wp#Curation:AOP
http://vocabularies.wikipathways.org/wp#Curation:AnalysisCollection
http://vocabularies.wikipathways.org/wp#organism
http://purl.obolibrary.org/obo/NCBITaxon_9606
http://vocabularies.wikipathways.org/wp#organismName http://vocabularies.wikipathways.org/wp#pathwayOntologyTag
http://purl.obolibrary.org/obo/PW_0001435
http://purl.obolibrary.org/obo/PW_0000003
http://xmlns.com/foaf/0.1/img
https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=svg&pwTitle=Pathway:WP2643&oldid=137818
https://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP2643&oldid=137818
https://identifiers.org/wikipathways/WP254 https://identifiers.org/pubmed/23428231 https://identifiers.org/wikidata/Q101991 https://identifiers.org/wikidata/Q189092 https://identifiers.org/wikidata/Q189159 https://identifiers.org/wikidata/Q210861 https://identifiers.org/wikipathways/WP2643 https://identifiers.org/uniprot/O00329 https://identifiers.org/uniprot/O15264 https://identifiers.org/uniprot/P00533 https://identifiers.org/uniprot/P01111 https://identifiers.org/uniprot/P01112 https://identifiers.org/uniprot/P02452 https://identifiers.org/uniprot/P02751 https://identifiers.org/uniprot/P04049 https://identifiers.org/uniprot/P05556 https://identifiers.org/uniprot/P12931 https://identifiers.org/uniprot/P28482 https://identifiers.org/uniprot/P36507 https://identifiers.org/uniprot/P45983 https://identifiers.org/uniprot/P45984 https://identifiers.org/uniprot/P49023 https://identifiers.org/uniprot/P53778 https://identifiers.org/uniprot/P53779 https://identifiers.org/uniprot/Q02750 https://identifiers.org/uniprot/Q07889 https://identifiers.org/uniprot/Q15759 https://identifiers.org/uniprot/Q16539 https://identifiers.org/uniprot/Q9Y243 https://identifiers.org/wikidata/Q424361 https://identifiers.org/uniprot/P15514 https://identifiers.org/uniprot/P01116 https://identifiers.org/uniprot/P56199 https://identifiers.org/uniprot/P62993 https://identifiers.org/uniprot/Q05397 https://identifiers.org/uniprot/Q9Y490 https://identifiers.org/wikipathways/WP1539